Otitis media and interna with or without polyps in cats: association between meningeal enhancement on postcontrast MRI, cerebrospinal fluid abnormalities, and clinician treatment choice and outcome.

Dutil, Guillaume F; Guevar, Julien; Schweizer, Daniela; Roosje, Petra; Kajin, Filip; Volk, Holger A; Grapes, Nick J; De Decker, Steven; Gutierrez-Quintana, Rodrigo; Abouzeid, Jad; Freeman, Paul; Faller, Kiterie Me; Stein, Veronika M; Maiolini, Arianna (2022). Otitis media and interna with or without polyps in cats: association between meningeal enhancement on postcontrast MRI, cerebrospinal fluid abnormalities, and clinician treatment choice and outcome. Journal of feline medicine and surgery, 24(12), e481-e489. Sage 10.1177/1098612X221125573

[img] Text
1098612x221125573.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.
Author holds Copyright

Download (468kB) | Request a copy

OBJECTIVES

The aim of this study was to evaluate the association between meningeal enhancement (MgE) and cerebrospinal fluid (CSF) analysis results, their individual association with bacteriology results from affected ear samples and whether these test results influenced clinicians' therapeutic choice in cats with otitis media and interna (OMI).

METHODS

This was a multicentre retrospective study carried out over an 8-year period. Cats diagnosed with OMI, with or without a nasopharyngeal polyp, leading to peripheral vestibular signs were included. Only cats for which MRI with postcontrast T1-weighted sequences and CSF analyses available were included. Cats with intra-axial MRI lesions or empyema were excluded.

RESULTS

Fifty-eight cats met the inclusion criteria. MgE was reported in 26/58 cases, of which nine had an abnormal CSF result (increased total nucleated cell count [TNCC] or total protein); 32/58 cases had no MgE, of which 10 showed abnormal CSF results. There was no association between bacteriology results (external ear canal or bulla) and MgE or abnormal CSF results. CSF abnormalities were statistically significantly more common in acute cases (n = 16/37) than in chronic cases (n = 3/21; Fischer's test P = 0.04). Prednisolone was prescribed in 10/16 cases with increased TNCC. Among the 42 cases with normal TNCC, 15 received prednisolone and 13 received non-steroidal anti-inflammatory drugs. Various antimicrobial drugs were prescribed in 53/58 cats. Duration of antimicrobial treatment was similar, regardless of positive bacterial culture (5.58 vs 4.22 weeks), abnormal CSF (5.83 vs 4.76 weeks) or MgE (5.33 vs 4.90 weeks).

CONCLUSIONS AND RELEVANCE

No association was found between the CSF and MgE results. Furthermore, no association was found between MgE, CSF or bacteriology findings. In addition, abnormal CSF results might lead the clinician to treat with corticosteroids, but they did not have any impact on duration of antimicrobial treatment. CSF abnormalities were seen significantly less frequently in chronic cases. The outcome tended to be poorer when MgE was detected on MRI.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology

UniBE Contributor:

Dutil, Guillaume Fabien, Guevar, Julien Jean, Schweizer, Daniela Esther, Roosje Hasler, Pieternella, Stein, Veronika Maria, Maiolini, Arianna

Subjects:

600 Technology > 630 Agriculture

ISSN:

1098-612X

Publisher:

Sage

Language:

English

Submitter:

Pubmed Import

Date Deposited:

22 Nov 2022 09:41

Last Modified:

02 Mar 2023 23:36

Publisher DOI:

10.1177/1098612X221125573

PubMed ID:

36409551

Uncontrolled Keywords:

MRI meningeal enhancement Otitis media and interna cerebrospinal fluid peripheral vestibular signs

BORIS DOI:

10.48350/175004

URI:

https://boris.unibe.ch/id/eprint/175004

Actions (login required)

Edit item Edit item
Provide Feedback