Ruperti-Repilado, Francisco Javier; Baumgartner, Helmut; Bouma, Berto; Bouchardy, Judith; Budts, Werner; Campens, Laurence; Chessa, Massimo; Jesús Del Cerro Marin, Maria; Gabriel, Harald; Gallego, Pastora; González, Elvira Ana; Jensen, Annette Schophuus; Ladouceur, Magalie; Lockhart, Christopher; Miranda-Barrio, Berta; Morissens, Marielle; Escobar, Eduardo Moreno; Pasquet, Agnès; Soriano, Joaquin Rueda; Elise van den Bosch, Annemien; ... (2023). The coronavirus disease pandemic among adult congenital heart disease patients and the lessons learnt - results of a prospective multicenter european registry. International journal of cardiology. Congenital heart disease., 11(100428), p. 100428. Elsevier 10.1016/j.ijcchd.2022.100428
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BACKGROUND
At the beginning of the COVID-19 pandemic, professionals in charge of particularly vulnerable populations, such as adult congenital heart disease (ACHD) patients, were confronted with difficult decision-making. We aimed to assess changes in risk stratification and outcomes of ACHD patients suffering from COVID-19 between March 2020 and April 2021.
METHODS AND RESULTS
Risk stratification among ACHD experts (before and after the first outcome data were available) was assessed by means of questionnaires. In addition, COVID-19 cases and the corresponding patient characteristics were recorded among participating centres. Predictors for the outcome of interest (complicated disease course) were assessed by means of multivariable logistic regression models calculated with cluster-robust standard errors. When assessing the importance of general and ACHD specific risk factors for a complicated disease course, their overall importance and the corresponding risk perception among ACHD experts decreased over time. Overall, 638 patients (n = 168 during the first wave and n = 470 during the subsequent waves) were included (median age 34 years, 52% women). Main independent predictors for a complicated disease course were male sex, increasing age, a BMI >25 kg/m2, having ≥2 comorbidities, suffering from a cyanotic heart disease or having suffered COVID-19 in the first wave vs. subsequent waves.
CONCLUSIONS
Apart from cyanotic heart disease, general risk factors for poor outcome in case of COVID-19 reported in the general population are equally important among ACHD patients. Risk perception among ACHD experts decreased during the course of the pandemic.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Ruperti Repilado, Francisco Javier, Schwerzmann, Markus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2666-6685 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
29 Nov 2022 15:04 |
Last Modified: |
07 Dec 2022 00:16 |
Publisher DOI: |
10.1016/j.ijcchd.2022.100428 |
PubMed ID: |
36440468 |
Uncontrolled Keywords: |
Adult congenital heart disease Coronavirus disease 2019 Outcomes Risk stratification |
BORIS DOI: |
10.48350/175257 |
URI: |
https://boris.unibe.ch/id/eprint/175257 |
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