Seyed Jafari, S. Morteza; Cazzaniga, Simone; Bossart, Simon; Feldmeyer, Laurence; Pelloni, Lorenzo; van Rhyn, Maja; Angermeier, Sarina; Adatto, Maurice; Hunger, Robert E.; Heidemeyer, Kristine (2022). Efficacy Assessment of the High-Frequency High-Intensity Focused Ultrasound as a New Treatment for Actinic Keratosis. Dermatology, 238(4), pp. 662-667. Karger 10.1159/000520536
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BACKGROUND
Actinic keratosis (AK) is the most common precancerous cutaneous lesion, with risk of progression to cutaneous squamous cell carcinoma. In the current study, we evaluated the efficacy of 20-MHz high-intensity focused ultrasound (HIFU), as a new treatment modality for AK.
MATERIALS AND METHODS
Patients with AK lesions (grades I-III) treated with HIFU were included in the study. The clinical assessment was performed 3 months after therapy.
RESULTS
Twenty-one patients (14 men, 7 women) with 108 AK lesions (grades I-III) were included in the current study. Ages ranged from 62 to 85 years (mean 72.6 years). Clinically complete resolution of the actinic damage in the treated area was detected in 72.2% of lesions. Furthermore, 28 lesions (26%) showed a reduction of the AK grade, or partial response, after the therapy. Most of the patients experienced annoying but short pain during the procedure. However, late adverse effects of the therapy, such as hypopigmentation, hyperpigmentation and erythema were reported only in a small portion of the lesions.
CONCLUSIONS
20-MHz HIFU could be an effective and safe alternative treatment for AK.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Jafari, Morteza, Cazzaniga, Simone, Bossart, Simon, Feldmeyer, Laurence, Pelloni, Lorenzo Stefano, Van Rhyn, Maja, Angermeier, Sarina, Adatto, Maurice Alfred, Hunger, Robert, Heidemeyer, Kristine |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1018-8665 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Andrea Studer-Gauch |
Date Deposited: |
30 Nov 2022 09:06 |
Last Modified: |
02 Mar 2023 23:36 |
Publisher DOI: |
10.1159/000520536 |
PubMed ID: |
34933303 |
Uncontrolled Keywords: |
Actinic keratosis High-frequency high-intensity ultrasound High-intensity focused ultrasound |
BORIS DOI: |
10.48350/175266 |
URI: |
https://boris.unibe.ch/id/eprint/175266 |
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