Efficacy Assessment of the High-Frequency High-Intensity Focused Ultrasound as a New Treatment for Actinic Keratosis.

Seyed Jafari, S. Morteza; Cazzaniga, Simone; Bossart, Simon; Feldmeyer, Laurence; Pelloni, Lorenzo; van Rhyn, Maja; Angermeier, Sarina; Adatto, Maurice; Hunger, Robert E.; Heidemeyer, Kristine (2022). Efficacy Assessment of the High-Frequency High-Intensity Focused Ultrasound as a New Treatment for Actinic Keratosis. Dermatology, 238(4), pp. 662-667. Karger 10.1159/000520536

[img] Text
document.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB)

BACKGROUND

Actinic keratosis (AK) is the most common precancerous cutaneous lesion, with risk of progression to cutaneous squamous cell carcinoma. In the current study, we evaluated the efficacy of 20-MHz high-intensity focused ultrasound (HIFU), as a new treatment modality for AK.

MATERIALS AND METHODS

Patients with AK lesions (grades I-III) treated with HIFU were included in the study. The clinical assessment was performed 3 months after therapy.

RESULTS

Twenty-one patients (14 men, 7 women) with 108 AK lesions (grades I-III) were included in the current study. Ages ranged from 62 to 85 years (mean 72.6 years). Clinically complete resolution of the actinic damage in the treated area was detected in 72.2% of lesions. Furthermore, 28 lesions (26%) showed a reduction of the AK grade, or partial response, after the therapy. Most of the patients experienced annoying but short pain during the procedure. However, late adverse effects of the therapy, such as hypopigmentation, hyperpigmentation and erythema were reported only in a small portion of the lesions.

CONCLUSIONS

20-MHz HIFU could be an effective and safe alternative treatment for AK.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Jafari, Morteza, Cazzaniga, Simone, Bossart, Simon, Feldmeyer, Laurence, Pelloni, Lorenzo Stefano, Van Rhyn, Maja, Angermeier, Sarina, Adatto, Maurice Alfred, Hunger, Robert, Heidemeyer, Kristine

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1018-8665

Publisher:

Karger

Language:

English

Submitter:

Andrea Studer-Gauch

Date Deposited:

30 Nov 2022 09:06

Last Modified:

02 Mar 2023 23:36

Publisher DOI:

10.1159/000520536

PubMed ID:

34933303

Uncontrolled Keywords:

Actinic keratosis High-frequency high-intensity ultrasound High-intensity focused ultrasound

BORIS DOI:

10.48350/175266

URI:

https://boris.unibe.ch/id/eprint/175266

Actions (login required)

Edit item Edit item
Provide Feedback