Distribution of oral nutritional supplements with medication: Is there a benefit? A systematic review.

Krebs, Fabian; Uhlmann, Katja; Stanga, Zeno; Kurmann, Silvia (2022). Distribution of oral nutritional supplements with medication: Is there a benefit? A systematic review. Nutrition, 96, p. 111569. Elsevier 10.1016/j.nut.2021.111569

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OBJECTIVES

Disease-related malnutrition remains a major burden for patients and health care systems. The Medication Pass Nutritional Supplement Program (MEDPass) involves providing patients with oral nutritional supplements (ONS) in unusually small amounts three to four times per day during medication rounds. This systematic review aims to evaluate the impact of MEDPass ONS administration on compliance, total energy and protein intake, food intake, body weight and handgrip strength in hospitalized adults and nursing-home residents.

METHODS

We conducted a systematic literature search in the databases MEDLINE, Embase, ScienceDirect, and the Cochrane Library and included randomized controlled trials (RCTs), non-RCTs, and before-after studies. Validated tools specific to the study design were used to assess the included studies.

RESULTS

Ten studies were identified, including two RCTs, three non-RCTs, and five before-after trials. Compliance increased by 23.4% to 66% with MEDPass administration, resulting in compliance rates of 72.7% to 96%. With MEDPass administration, body weight increased by 1% to 6.8% or remained stable. The assessed evidence on total energy intake is ambiguous for protein, with a trend toward an increased intake. Trials on energy intake from food show mixed results as well. One study suggested a slight increase in handgrip strength. The included studies predominantly raise concerns for bias.

CONCLUSIONS

We conclude that MEDPass ONS administration increases compliance in hospitalized adults and nursing-home residents. For all other outcomes, robust and well-powered trials are necessary.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Stanga, Zeno

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0899-9007

Publisher:

Elsevier

Language:

English

Submitter:

Laura Goetschi

Date Deposited:

13 Dec 2022 10:23

Last Modified:

18 Dec 2022 02:06

Publisher DOI:

10.1016/j.nut.2021.111569

PubMed ID:

35074646

Uncontrolled Keywords:

Body weight Compliance Energy MEDPass Oral nutritional supplements Protein handgrip strength

BORIS DOI:

10.48350/175777

URI:

https://boris.unibe.ch/id/eprint/175777

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