Grädel, Flavia; von Wolff, Michael; Kohl Schwartz, Alexandra Sabrina; Mitter, Vera Ruth (2023). Low-dose clomiphene citrate does not reduce implantation and live birth rates in otherwise unstimulated modified natural cycle IVF-retrospective cohort study. Archives of gynecology and obstetrics, 307(4), pp. 1073-1081. Springer-Verlag 10.1007/s00404-022-06878-6
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RESEARCH QUESTION
Does antioestrogen effect of clomiphene citrate (CC) on the endometrium reduce implantation and thereby decrease pregnancy and live birth rate per transferred embryo?
METHODS
In this cohort, unstimulated IVF cycles modified with clomiphene citrate (CC-NC-IVF) and unstimulated, natural IVF cycles (NC-IVF) conducted between 2011 and 2016 were included. CC was applied in a dosage of 25mcg per day, starting on cycle day 7 until ovulation trigger day. Primary outcomes were clinical pregnancy rate, defined as amniotic sac visible in ultrasound, and live birth rate per transferred embryo. Miscarriage rate calculated as amniotic sac not ending in a live birth was secondary outcome. A modified mixed-effect Poisson regression model was applied, and adjustments were made for female age, parity, type and cause of infertility. Additionally, stratification by parity and age was performed.
RESULTS
Four hundred and ninety-nine couples underwent a total of 1042 IVF cycles, 453 being NC-IVF and 589 being CC-NC-IVF cycles. Baseline characteristics of both groups did not differ. Addition of CC did neither decrease clinical pregnancy rate (aRR 0.86; 95% CI 0.67-1.12) nor live birth rate per transferred embryo (aRR 0.84; 95% CI 0.62-1.13) in comparison with NC-IVF. Miscarriage rate did not differ between CC-NC-IVF and NC-IVF (aRR 0.95; 95% CI 0.57-1.57).
CONCLUSION
Low-dose CC does not reduce pregnancy or live birth rate per transferred embryo. It can be used in infertility treatment without negatively affecting the endometrium and implantation.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
von Wolff, Michael, Kohl Schwartz, Alexandra, Mitter, Vera Ruth |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0932-0067 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 Dec 2022 10:37 |
Last Modified: |
18 Mar 2023 00:13 |
Publisher DOI: |
10.1007/s00404-022-06878-6 |
PubMed ID: |
36525092 |
Uncontrolled Keywords: |
Bern IVF Cohort Clinical pregnancy Endometrium FIVNAT Modified natural-cycle Pregnancy rate |
BORIS DOI: |
10.48350/176019 |
URI: |
https://boris.unibe.ch/id/eprint/176019 |
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