Comparing radiolytic production of H2O2 and development of Zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams.

Kacem, Houda; Psoroulas, Serena; Boivin, Gael; Folkerts, Michael; Grilj, Veljko; Lomax, Tony; Martinotti, Adrien; Meer, David; Ollivier, Jonathan; Petit, Benoit; Safai, Sairos; Sharma, Ricky A; Togno, Michele; Vilalta, Marta; Weber, Damien C; Vozenin, Marie-Catherine (2022). Comparing radiolytic production of H2O2 and development of Zebrafish embryos after ultra high dose rate exposure with electron and transmission proton beams. Radiotherapy and oncology, 175, pp. 197-202. Elsevier 10.1016/j.radonc.2022.07.011

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The physico-chemical and biological response to conventional and UHDR electron and proton beams was investigated, along with conventional photons. The temporal structure and nature of the beam affected both, with electron beam at ≥1400 Gy/s and proton beam at 0.1 and 1260 Gy/s found to be isoefficient at sparing zebrafish embryos.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Weber, Damien Charles

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0167-8140

Publisher:

Elsevier

Language:

English

Submitter:

Basak Ginsbourger

Date Deposited:

27 Dec 2022 15:08

Last Modified:

27 Dec 2022 23:08

Publisher DOI:

10.1016/j.radonc.2022.07.011

PubMed ID:

35868604

Uncontrolled Keywords:

Electron FLASH Hydrogen peroxyde Proton FLASH Zebrafish embryos

BORIS DOI:

10.48350/176383

URI:

https://boris.unibe.ch/id/eprint/176383

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