Vaiman, Elena E; Shnayder, Natalia A; Zhuravlev, Nikita M; Petrova, Marina M; Asadullin, Azat R; Al-Zamil, Mustafa; Garganeeva, Natalia P; Shipulin, German A; Cumming, Paul; Nasyrova, Regina F (2022). Genetic Biomarkers of Antipsychotic-Induced Prolongation of the QT Interval in Patients with Schizophrenia. International journal of molecular sciences, 23(24) MDPI 10.3390/ijms232415786
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Antipsychotics (AP) induced prolongation of the QT interval in patients with schizophrenia (Sch) is an actual interdisciplinary problem as it increases the risk of sudden death syndrome. Long QT syndrome (LQTS) as a cardiac adverse drug reaction is a multifactorial symptomatic disorder, the development of which is influenced by modifying factors (APs' dose, duration of APs therapy, APs polytherapy, and monotherapy, etc.) and non-modifying factors (genetic predisposition, gender, age, etc.). The genetic predisposition to AP-induced LQTS may be due to several causes, including causal mutations in the genes responsible for monoheme forms of LQTS, single nucleotide variants (SNVs) of the candidate genes encoding voltage-dependent ion channels expressed both in the brain and in the heart, and SNVs of candidate genes encoding key enzymes of APs metabolism. This narrative review summarizes the results of genetic studies on AP-induced LQTS and proposes a new personalized approach to assessing the risk of its development (low, moderate, high). We recommend implementation in protocols of primary diagnosis of AP-induced LQTS and medication dispensary additional observations of the risk category of patients receiving APs, deoxyribonucleic acid profiling, regular electrocardiogram monitoring, and regular therapeutic drug monitoring of the blood APs levels.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Cumming, Paul |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1422-0067 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
09 Jan 2023 13:41 |
Last Modified: |
10 Jan 2023 15:23 |
Publisher DOI: |
10.3390/ijms232415786 |
PubMed ID: |
36555428 |
Uncontrolled Keywords: |
adverse drug reaction antipsychotic-induced repolarization disorder antipsychotics cardiac repolarization long QT interval pharmacogenetics schizophrenia sudden death syndrome ventricular tachyarrhythmia |
BORIS DOI: |
10.48350/176503 |
URI: |
https://boris.unibe.ch/id/eprint/176503 |
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