The Role of Active or Passive Drainage after Evacuation of Chronic Subdural Hematoma: An Analysis of Two Randomized Controlled Trials (cSDH-Drain-Trial and TOSCAN Trial).

Ebel, Florian; Greuter, Ladina; Lutz, Katharina; Häni, Levin; Fandino, Javier; Guzman, Raphael; Mariani, Luigi; Beck, Jürgen; Raabe, Andreas; Z'Graggen, Werner J; Schucht, Philippe; Soleman, Jehuda (2022). The Role of Active or Passive Drainage after Evacuation of Chronic Subdural Hematoma: An Analysis of Two Randomized Controlled Trials (cSDH-Drain-Trial and TOSCAN Trial). Diagnostics, 12(12) MDPI 10.3390/diagnostics12123045

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The evacuation of a chronic subdural hematoma (cSDH) is one of the most common procedures in neurosurgery. The aim of this study was to assess the influence of drainage suction in the surgical treatment of cSDH on the recurrence rate. Post hoc analysis was conducted on two randomized controlled trials (cSDH-Drain-Trial and TOSCAN trial) stratifying a total of 581 patients into active or passive drain type. Of the 581 patients, 359 (61.8%) and 220 (37.9%) were stratified into the active and passive drainage groups, respectively. The reoperation rate following postoperative recurrence was 23.1% and 14.1% in the active and passive drainage groups, respectively (p < 0.011). After propensity score matching, the differences in recurrence rate remained significant (26.6% versus 15.6%, p = 0.012). However, the functional outcome (mRS) at 6-12 months did not differ significantly (median [IQR]) between the 2 groups (passive drainage group 0.00 [0.00, 2.00], active drainage group 1.00 [0.00, 2.00], p = 0.431). Mortality was comparable between the groups (passive drainage group 12 (5.5%), active drainage group 20 (5.6%), p = 0.968). In the univariate analysis, active drainage, short (<48 h) duration of drainage, and early (<48 h) postoperative mobilization were significantly associated with a higher recurrence rate. However, the multivariate logistic regression model could not confirm that any of these parameters were significantly associated with recurrence. Our post hoc analysis proposes that using a passive instead of an active drain might be associated with a reduced recurrence rate after evacuation of a cSDH. We suggest gathering further evidence by means of a randomized controlled trial.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Ebel, Florian Marc, Lutz, Katharina Sarah Jennifer, Häni, Levin, Beck, Jürgen, Raabe, Andreas, Z'Graggen, Werner Josef, Schucht, Philippe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2075-4418

Publisher:

MDPI

Language:

English

Submitter:

Pubmed Import

Date Deposited:

05 Jan 2023 10:21

Last Modified:

05 Jan 2023 23:23

Publisher DOI:

10.3390/diagnostics12123045

PubMed ID:

36553053

Uncontrolled Keywords:

burr hole trepanation chronic subdural hematoma drainage recurrence

BORIS DOI:

10.48350/176506

URI:

https://boris.unibe.ch/id/eprint/176506

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