Jeyaprakash, Nishanthini; Maeder, Sara; Janka, Heidrun; Stute, Petra (2023). A systematic review of the impact of 7-keto-DHEA on body weight. Archives of gynecology and obstetrics, 308(3), pp. 777-785. Springer-Verlag 10.1007/s00404-022-06884-8
|
Text
s00404-022-06884-8.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (841kB) | Preview |
7-Keto-DHEA has been commercially advertised as a dietary supplement to support weight loss. The objective of the present systematic review it to summarize the evidence supporting the use of 7-keto-DHEA in overweight and obese population. The systematic search was conducted in Medline, Embase, Cochrane Library, CINAHL, Web of Science, Scopus, ICTRP, and ClinicalTrials.gov. Additionally, reference lists of eligible studies were considered, and authors of relevant studies were contacted. Two authors independently screened the studies against the inclusion criteria and assessed their risk of bias. In total, 4 out of 686 studies were included in the review. They all held a low risk of bias. Half of them showed a significant reduction in body weight. One study found a decrease in body fat percentage and another one reported a decrease in BMI. Two studies stated an increase in resting metabolic rate. No serious adverse effects were reported. Various possible mechanisms in favor of weight loss are discussed; however, with the evidence currently available, no clear answer can be given regarding 7-keto-DHEA and weight loss. Further studies need to be conducted to clarify the efficacy and safety of this drug before it can be recommended for therapeutic use.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
13 Central Units > Administrative Director's Office > University Library of Bern 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
Janka, Heidrun Ilonka, Stute, Petra |
Subjects: |
000 Computer science, knowledge & systems > 020 Library & information sciences 600 Technology > 610 Medicine & health |
ISSN: |
0932-0067 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
05 Jan 2023 13:00 |
Last Modified: |
15 Jul 2023 00:12 |
Publisher DOI: |
10.1007/s00404-022-06884-8 |
PubMed ID: |
36566478 |
Uncontrolled Keywords: |
3-Acetyl-7-oxo-dehydroepiandrosterone 7-Keto-DHEA Obesity Weight loss |
BORIS DOI: |
10.48350/176532 |
URI: |
https://boris.unibe.ch/id/eprint/176532 |
Actions (login required)
 |
Edit item |