Turner, Katherine; Castelnovo, Anna; Perogamvros, Lampros; Cloninger, Robert C; Galbiati, Andrea; Bertolotti, Alessia; Proserpio, Paola; Terzaghi, Michele; Manni, Raffaele; Ferini Strambi, Luigi; Nobili, Lino; Manconi, Mauro; Canevini, Maria Paola; Zambrelli, Elena (2023). Psychobiological personality traits of children and adolescents with disorders of arousal. Journal of psychiatric research, 158, pp. 42-48. Elsevier 10.1016/j.jpsychires.2022.12.035
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INTRODUCTION
Disorders of arousal (DOA) are parasomnias that emerge from incomplete arousal out of Non-Rem Sleep (NREM) and lead to a broad variety of emotional and motor behaviours. Increasing evidence supports the hypothesis that specific psychopathological traits contribute to the multifactorial origin of these phenomena. The aim of the current multicenter study was to compare the personality profile of children and adolescents with and without DOA using the Junior Temperament and Character Inventory (JTCI).
METHODS
We enrolled 36 patients with a diagnosis of DOA (mean age of 11 ± 3 years, 64% males), and 36 healthy age and gender matched control subjects (mean age of 11.2 ± 3.6, years, 67% males). Their parents completed the Paris Arousal Disorder Severity Scale (PADSS), the Sleep Disturbance Scale for Children (SDSC) and the JTCI.
RESULTS
Patients with DOA reached significantly higher levels compared to their control group in total PADSS (p < 0.0001) and in total SDSC (p < 0.0001). They also displayed higher scores in novelty seeking (p = 0.005), harm avoidance (p = 0.01), self-transcendence (p = 0.006) JTCI subscales, and lower scores on the self-directedness subscale (p = 0.004).
CONCLUSION
Our pediatric sample with DOA exhibited specific psychobiological personality traits compared to age and gender matched subjects without DOA. These results shed light on new possible etiopathogenetic mechanisms, as TCI traits have been linked to specific genetic variants and brain circuits, like the reward system. Prospective studies are required to assess the effect of targeted psychological/psychiatric treatment on DOA symptomatology.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Manconi, Mauro |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0022-3956 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
06 Jan 2023 09:32 |
Last Modified: |
04 Feb 2023 00:15 |
Publisher DOI: |
10.1016/j.jpsychires.2022.12.035 |
PubMed ID: |
36571910 |
Uncontrolled Keywords: |
Confusional arousal NREM sleep parasomnias Night terror Psychopathology Sleepwalking Somnambulism |
BORIS DOI: |
10.48350/176549 |
URI: |
https://boris.unibe.ch/id/eprint/176549 |
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