Spindler, Volker; Gerull, Brenda; Green, Kathleen J; Kowalczyk, Andrew P; Leube, Rudolf; Marian, Ali J; Milting, Hendrik; Müller, Eliane J; Niessen, Carien; Payne, Aimee S; Schlegel, Nicolas; Schmidt, Enno; Strnad, Pavel; Tikkanen, Ritva; Vielmuth, Franziska; Waschke, Jens (2023). Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting. Journal of cell science, 136(1) Company of Biologists Limited 10.1242/jcs.260832
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Desmosome diseases are caused by dysfunction of desmosomes, which anchor intermediate filaments (IFs) at sites of cell-cell adhesion. For many decades, the focus of attention has been on the role of actin filament-associated adherens junctions in development and disease, especially cancer. However, interference with the function of desmosomes, their molecular constituents or their attachments to IFs has now emerged as a major contributor to a variety of diseases affecting different tissues and organs including skin, heart and the digestive tract. The first Alpine desmosome disease meeting (ADDM) held in Grainau, Germany, in October 2022 brought together international researchers from the basic sciences with clinical experts from diverse fields to share and discuss their ideas and concepts on desmosome function and dysfunction in the different cell types involved in desmosome diseases. Besides the prototypic desmosomal diseases pemphigus and arrhythmogenic cardiomyopathy, the role of desmosome dysfunction in inflammatory bowel diseases and eosinophilic esophagitis was discussed.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology |
UniBE Contributor: |
Müller, Eliane Jasmine |
Subjects: |
600 Technology > 610 Medicine & health 600 Technology > 630 Agriculture |
ISSN: |
0021-9533 |
Publisher: |
Company of Biologists Limited |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Jan 2023 12:35 |
Last Modified: |
11 Jan 2023 23:23 |
Publisher DOI: |
10.1242/jcs.260832 |
PubMed ID: |
36594662 |
BORIS DOI: |
10.48350/176789 |
URI: |
https://boris.unibe.ch/id/eprint/176789 |
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