The provisional OMERACT ultrasonography score for giant cell arteritis.

Dejaco, Christian; Ponte, Cristina; Monti, Sara; Rozza, Davide; Scirè, Carlo Alberto; Terslev, Lene; Bruyn, George A W; Boumans, Dennis; Hartung, Wolfgang; Hočevar, Alojzija; Milchert, Marcin; Døhn, Uffe Møller; Mukhtyar, Chetan B; Aschwanden, Markus; Bosch, Philipp; Camellino, Dario; Chrysidis, Stavros; Ciancio, Giovanni; D'Agostino, Maria Antonietta; Daikeler, Thomas; ... (2023). The provisional OMERACT ultrasonography score for giant cell arteritis. Annals of the rheumatic diseases, 82(4), pp. 556-564. BMJ Publishing Group 10.1136/ard-2022-223367

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To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties.


The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24.


Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from -1.19 to -2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corrcoeff 0.37-0.48).


We developed a provisional OGUS for potential use in clinical trials.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Seitz, Luca Fabio


600 Technology > 610 Medicine & health




BMJ Publishing Group




Pubmed Import

Date Deposited:

09 Jan 2023 12:07

Last Modified:

02 Oct 2023 00:11

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

giant cell arteritis outcome assessment, health care systemic vasculitis ultrasonography




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