Clomiphene citrate stimulated cycles - additional gonadotrophin stimulation increases endometrium thickness without increasing implantation rate.

Magaton, I; Helmer, A; Roumet, M; Stute, P; von Wolff, M (2022). Clomiphene citrate stimulated cycles - additional gonadotrophin stimulation increases endometrium thickness without increasing implantation rate. Facts, views & vision in ObGyn, 14(1), pp. 77-81. Universa Press 10.52054/FVVO.14.1.013

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It is known that Clomiphene citrate (CC) reduces endometrial thickness, but it is unknown if additional gonadotrophin stimulation increases endometrial thickness and if this has an effect on implantation rate in in vitro fertilization (IVF). The retrospective study included 263 minimal stimulation IVF-cycles stimulated with 25 mg CC per day (CC-IVF), and 161 IVF-cycles stimulated with CC plus 75IU hMG (human Menopausal Gonadotrophin) per day (CC/hMG-IVF). Endometrial and oestradiol (E2) measurements were analysed between day -4 and 0 (0 = day of oocyte retrieval) and the association of endometrial thickness and treatment on implantation rates were studied after multiple adjustments. It was shown that on day 0, endometrium was significantly thicker in CC/hMG-IVF versus CC-IVF cycles (9.81 ±2.68 versus 9.06 ±2.54 mm, p = 0.005). However, increased endometrial thickness did not have an effect on implantation and live birth rates. In conclusion, gonadotrophins should not be added to low dose CC treated IVF cycles just to increase endometrial thickness as increased endometrial thickness does not increase implantation rate.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Magaton, Isotta Martha, Roumet, Marie Camille, Stute, Petra, von Wolff, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2032-0418

Publisher:

Universa Press

Language:

English

Submitter:

Monika Zehr

Date Deposited:

11 Jan 2023 15:22

Last Modified:

20 Feb 2024 14:16

Publisher DOI:

10.52054/FVVO.14.1.013

PubMed ID:

35373551

BORIS DOI:

10.48350/176824

URI:

https://boris.unibe.ch/id/eprint/176824

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