Kindler, Jochen (7 April 2022). Toll-like receptor MRNA levels and cingulate gyrus cortical thickness in schizophrenia (Unpublished). In: SIRS 2022. Florenz, Italien. 06.04.-10.04.2022.
Background: Increased cytokines of the innate immune system are found in schizophrenia and may be caused by alterations in endogenous pathogen recognition receptors upstream of cytokines. Toll like receptors (TLR) expressed on sentinel immune cells are cell surface receptors activated by bacteria (activating TLR1, TLR4), viruses (activating TLR3) or both (activating TLR8). We tested whether peripheral TLR1, TLR3, TLR4 and TLR8 mRNA levels differed between schizophrenia and healthy controls and if TLR mRNA levels were elated to proinflammatory cytokines and cingulate gyrus cortical thickness.
Methods: Peripheral TLR mRNA levels and proinflammatory cytokine mRNAs were extracted from white blood cells of 86 people with schizophrenia and 77 controls by RT-PCR and structural 3-T Magnetic Resonance Imaging scans were acquired in 51/86 people with schizophrenia and 57/77 controls.
Results: TLR4 and TLR8 mRNA levels were significantly increased and TLR3 mRNA levels were significantly decreased in schizophrenia versus controls. Proinflammatory cytokine subgroups had a significant influence on mRNA levels of all TLRs. Cingulate gyrus cortical thickness was inversely associated with TLR8 mRNA levels in schizophrenia and with TLR4 and TLR8 levels in controls.
Conclusions: Our results suggest more bacterial (based on TLR4 levels) relative to viral influence in the inflammatory response characteristic of schizophrenia. TLR4 and TLR8 expression was inversely related to cingulate gyrus thickness in schizophrenia and controls. Thus, the cingulate cortex may be particularly vulnerable to inflammation.
Item Type: |
Conference or Workshop Item (Speech) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division |
UniBE Contributor: |
Kindler, Jochen |
Subjects: |
600 Technology > 610 Medicine & health |
Language: |
English |
Submitter: |
Chantal Michel |
Date Deposited: |
09 Jan 2023 13:46 |
Last Modified: |
09 Jan 2023 23:23 |
URI: |
https://boris.unibe.ch/id/eprint/176837 |
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