Galli, Jonas; Giger, Roland; Elicin, Olgun; Wartenberg, Martin; Anschuetz, Lukas; Nisa, Lluís (2022). Diagnostic accuracy of MRI and PET/CT for neck staging prior to salvage total laryngectomy. Journal of Cancer Metastasis and Treatment, 8(48) OAE Publishing 10.20517/2394-4722.2022.19
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Aim: Lymph node (LN) metastases are associated with poor outcomes in patients with recurrent larynx squamous cell carcinoma (LSCC). Neck dissection (ND) is therefore commonly performed along with salvage total laryngectomy (STL). Here, we assess the rate of occult LN metastases and the diagnostic value of MRI and PET/CT for detecting them in recurrent LSCC.
Methods: This retrospective study included patients with recurrent LSCC after primary (chemo)radiotherapy [(C)RT] who were re-staged by MRI and/or PET/CT and treated with STL and ND between 2004 and 2019. The histopathology of ND samples was used as the reference standard.
Results: Forty-one patients were included. The prevalence of occult metastases in MRI-negative and PET/CT-negative neck nodes was between 3.2% and 6.1%. Negative predictive values of neck node re-staging were 93.9% for MRI, 96.8% for PET/CT, and 96.2% for MRI and PET/CT combined.
Conclusion: Both MRI and PET/CT afforded good negative predictive values for nodal staging in patients with recurrent LSCC after (C)RT prior to STL. In selected patients, these radiological modalities, particularly PET/CT, could help to avoid unnecessary surgery to the neck and its associated morbidity.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) |
UniBE Contributor: |
Galli, Jonas Michael, Giger, Roland, Eliçin, Olgun, Wartenberg, Martin, Anschütz, Lukas Peter, Nisa Hernandez, Lluis |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2454-2857 |
Publisher: |
OAE Publishing |
Language: |
English |
Submitter: |
Sven Beckmann |
Date Deposited: |
12 Jan 2023 09:24 |
Last Modified: |
12 Jan 2023 23:28 |
Publisher DOI: |
10.20517/2394-4722.2022.19 |
BORIS DOI: |
10.48350/176888 |
URI: |
https://boris.unibe.ch/id/eprint/176888 |
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