Cross-sectional study of intraocular cataract lens replacement, circadian rest-activity rhythms, and sleep quality in older adults.

Chellappa, Sarah L; Bromundt, Vivien; Frey, Sylvia; Schlote, Torsten; Goldblum, David; Cajochen, Christian (2022). Cross-sectional study of intraocular cataract lens replacement, circadian rest-activity rhythms, and sleep quality in older adults. Sleep, 45(4) Oxford University Press 10.1093/sleep/zsac027

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STUDY OBJECTIVES

Age-related cataract decreases light transmission at the most sensitive spectrum for circadian photoentrainment, with negative ramifications for human health. Here, we assessed whether intraocular lens replacement (IOL) in older patients with previous cataract was associated with increased stability and amplitude of circadian rest-activity rhythms, and improved sleep quality.

METHODS

Our cross-sectional study included sixteen healthy older individuals without ocular diseases (controls; 55-80 years; 63.6 ± 5.6y; 8 women) and 13 patients with previous cataract and bilateral IOL (eight with blue-blocking [BB] lens and five with ultraviolet-only [UV] blocking lens; 55-80 years; 69.9 ± 5.2y; 9 women). The study comprised three weeks of at home rest-activity assessments using wrist-worn actigraphs, and each week preceded a laboratory protocol. Primary outcomes were actigraphy-derived interdaily stability, intradaily variability, and relative amplitude of circadian rest-activity rhythms. Secondary outcomes were actigraphy-assessed sleep quality (i.e. time in bed, sleep duration, sleep efficiency, mean wake bout time and fragmentation index).

RESULTS

Patients with IOL had significantly higher interdaily stability ("Group" effect: pFDR =.001), but not intradaily variability ("Group" effect: pFDR = n.s.), and significantly higher relative amplitude of rest-activity rhythms ("Group" effect: pFDR < .001). Moreover, patients with IOL had significantly higher activity levels during the day and lower levels during the evening, as compared to healthy older controls ("Group" effect: pFDR = .03). Analyses of actigraphy-derived sleep parameters yielded no significant differences across groups ("Group" effect: all pFDR > .1).

CONCLUSIONS

Our cross-sectional study suggests that enhancing spectral lens transmission in patients with cataract may benefit their circadian health.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bromundt, Vivien Silja

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1550-9109

Publisher:

Oxford University Press

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

09 Jan 2023 08:40

Last Modified:

09 Jan 2023 23:23

Publisher DOI:

10.1093/sleep/zsac027

PubMed ID:

35084492

Uncontrolled Keywords:

alertness cataract circadian photosensitivity light exposure mood rest–activity rhythms sleep wearable technology

BORIS DOI:

10.48350/176988

URI:

https://boris.unibe.ch/id/eprint/176988

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