Trueb, Beat (2011). Biology of FGFRL1, the fifth fibroblast growth factor receptor. Cellular and molecular life sciences, 68(6), pp. 951-64. Basel: SP Birkhäuser Verlag Basel 10.1007/s00018-010-0576-3
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FGFRL1 (fibroblast growth factor receptor like 1) is the most recently discovered member of the FGFR family. It contains three extracellular Ig-like domains similar to the classical FGFRs, but it lacks the protein tyrosine kinase domain and instead contains a short intracellular tail with a peculiar histidine-rich motif. The gene for FGFRL1 is found in all metazoans from sea anemone to mammals. FGFRL1 binds to FGF ligands and heparin with high affinity. It exerts a negative effect on cell proliferation, but a positive effect on cell differentiation. Mice with a targeted deletion of the Fgfrl1 gene die perinatally due to alterations in their diaphragm. These mice also show bilateral kidney agenesis, suggesting an essential role for Fgfrl1 in kidney development. A human patient with a frameshift mutation exhibits craniosynostosis, arguing for an additional role of FGFRL1 during bone formation. FGFRL1 contributes to the complexity of the FGF signaling system.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology > Rheumatology [discontinued] |
UniBE Contributor: |
Trueb, Beat |
ISSN: |
1420-682X |
Publisher: |
SP Birkhäuser Verlag Basel |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:11 |
Last Modified: |
05 Dec 2022 14:01 |
Publisher DOI: |
10.1007/s00018-010-0576-3 |
PubMed ID: |
21080029 |
Web of Science ID: |
000287578700003 |
BORIS DOI: |
10.7892/boris.1771 |
URI: |
https://boris.unibe.ch/id/eprint/1771 (FactScience: 203791) |
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