Biology of FGFRL1, the fifth fibroblast growth factor receptor

Trueb, Beat (2011). Biology of FGFRL1, the fifth fibroblast growth factor receptor. Cellular and molecular life sciences, 68(6), pp. 951-64. Basel: SP Birkhäuser Verlag Basel 10.1007/s00018-010-0576-3

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FGFRL1 (fibroblast growth factor receptor like 1) is the most recently discovered member of the FGFR family. It contains three extracellular Ig-like domains similar to the classical FGFRs, but it lacks the protein tyrosine kinase domain and instead contains a short intracellular tail with a peculiar histidine-rich motif. The gene for FGFRL1 is found in all metazoans from sea anemone to mammals. FGFRL1 binds to FGF ligands and heparin with high affinity. It exerts a negative effect on cell proliferation, but a positive effect on cell differentiation. Mice with a targeted deletion of the Fgfrl1 gene die perinatally due to alterations in their diaphragm. These mice also show bilateral kidney agenesis, suggesting an essential role for Fgfrl1 in kidney development. A human patient with a frameshift mutation exhibits craniosynostosis, arguing for an additional role of FGFRL1 during bone formation. FGFRL1 contributes to the complexity of the FGF signaling system.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology > Rheumatology (discontinued)

UniBE Contributor:

Trueb, Beat

ISSN:

1420-682X

Publisher:

SP Birkhäuser Verlag Basel

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

26 Jun 2018 14:29

Publisher DOI:

10.1007/s00018-010-0576-3

PubMed ID:

21080029

Web of Science ID:

000287578700003

BORIS DOI:

10.7892/boris.1771

URI:

https://boris.unibe.ch/id/eprint/1771 (FactScience: 203791)

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