The efficacy of selection may increase or decrease with selfing depending upon the recombination environment.

Sianta, Shelley A; Peischl, Stephan; Moeller, David A; Brandvain, Yaniv (2023). The efficacy of selection may increase or decrease with selfing depending upon the recombination environment. Evolution, 77(2), pp. 394-408. Oxford University Press 10.1093/evolut/qpac013

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Much theory has focused on how a population's selfing rate affects the ability of natural selection to remove deleterious mutations from a population. However, most such theory has focused on mutations of a given dominance and fitness effect in isolation. It remains unclear how selfing affects the purging of deleterious mutations in a genome-wide context where mutations with different selection and dominance coefficients co-segregate. Here, we use individual-based forward simulations and analytical models to investigate how mutation, selection and recombination interact with selfing rate to shape genome-wide patterns of mutation accumulation and fitness. In addition to recovering previously described results for how selfing affects the efficacy of selection against mutations of a given dominance class, we find that the interaction of purifying selection against mutations of different dominance classes changes with selfing and recombination rates. In particular, when recombination is low and recessive deleterious mutations are common, outcrossing populations transition from purifying selection to pseudo-overdominance, dramatically reducing the efficacy of selection. At these parameter combinations, the efficacy of selection remains low until populations hit a threshold selfing rate, above which it increases. In contrast, selection is more effective in outcrossing than (partial) selfing populations when recombination rates are moderate to high and recessive deleterious mutations are rare.

Item Type:	Journal Article (Original Article)
Division/Institute:	08 Faculty of Science > Department of Biology > Bioinformatics and Computational Biology
UniBE Contributor:	Peischl, Stephan
ISSN:	1558-5646
Publisher:	Oxford University Press
Language:	English
Submitter:	Pubmed Import
Date Deposited:	10 Jan 2023 06:45
Last Modified:	06 Feb 2023 00:15
Publisher DOI:	10.1093/evolut/qpac013
PubMed ID:	36622723
Uncontrolled Keywords:	efficacy of selection genetic load mating systems pseudo-overdominance selective interference selfing
URI:	https://boris.unibe.ch/id/eprint/177114