Knappe, Luisa Maria; Verburg, Frederik Anton; Giovanella, Luca; Luster, Markus; Librizzi, Damiano (2023). Diagnostic value of FDG-PET/CT in the diagnostic work-up of inflammation of unknown origin. Nuklearmedizin, 62(1), pp. 27-33. Thieme 10.1055/a-1976-1765
Full text not available from this repository. (Request a copy)Introduction The present study aims to evaluate the clinical diagnostic value of FDG-PET/CT in patients with inflammation of unknown origin. Material and methods We retrospectively analyzed data of 130 patients who presented general inflammatory symptoms and/or elevated level of CRP and underwent FDG-PET/CT for the purpose of identifying unknown foci of inflammation. The accuracy of PET/CT findings was assessed against the standard of eventual clinical diagnosis e.g. results of pathology, microbiology or other imaging methods. Results In 99/130 patients (76 %) a final diagnosis was established, FDG-PET/CT showed a sensitivity and specificity of each 93 %. A decreased pseudocholinesterase is associated with a higher SUVmax value and with a higher CRP value whereas no significant relationship was found between elevated CRP values and the SUVmax, although higher CRP values are associated significantly with a true positive PET/CT result. Conclusion FDG-PET/CT is a highly sensitive, specific and accurate method for the detection of foci of inflammation of unknown origin. The combination of decreased pseudocholinesterase and increased CRP levels may be a useful tool to select patients for FDG PET/CT.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Knappe, Luisa Maria |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2567-6407 |
Publisher: |
Thieme |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
12 Jan 2023 11:45 |
Last Modified: |
08 Feb 2023 00:15 |
Publisher DOI: |
10.1055/a-1976-1765 |
PubMed ID: |
36623829 |
URI: |
https://boris.unibe.ch/id/eprint/177132 |
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