Locatelli, Giuseppe; Marques-Ferreira, Filipa; Katsoulas, Antonis; Kalaitzaki, Vasileia; Krueger, Martin; Ingold-Heppner, Barbara; Walthert, Sabrina; Sankowski, Roman; Prazeres da Costa, Olivia; Dolga, Amalia; Huber, Magdalena; Gold, Maike; Culmsee, Carsten; Waisman, Ari; Bechmann, Ingo; Milchevskaya, Vladislava; Prinz, Marco; Tresch, Achim; Becher, Burkhard and Buch, Thorsten (2023). IGF1R expression by adult oligodendrocytes is not required in the steady-state but supports neuroinflammation. GLIA, 71(3), pp. 616-632. Wiley-Blackwell 10.1002/glia.24299
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Glia_-_2022_-_Locatelli_-_IGF1R_expression_by_adult_oligodendrocytes_is_not_required_in_the_steady_state_but_supports.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (9MB) | Preview |
In the central nervous system (CNS), insulin-like growth factor 1 (IGF-1) regulates myelination by oligodendrocyte (ODC) precursor cells and shows anti-apoptotic properties in neuronal cells in different in vitro and in vivo systems. Previous work also suggests that IGF-1 protects ODCs from cell death and enhances remyelination in models of toxin-induced and autoimmune demyelination. However, since evidence remains controversial, the therapeutic potential of IGF-1 in demyelinating CNS conditions is unclear. To finally shed light on the function of IGF1-signaling for ODCs, we deleted insulin-like growth factor 1 receptor (IGF1R) specifically in mature ODCs of the mouse. We found that ODC survival and myelin status were unaffected by the absence of IGF1R until 15 months of age, indicating that IGF-1 signaling does not play a major role in post-mitotic ODCs during homeostasis. Notably, the absence of IGF1R did neither affect ODC survival nor myelin status upon cuprizone intoxication or induction of experimental autoimmune encephalomyelitis (EAE), models for toxic and autoimmune demyelination, respectively. Surprisingly, however, the absence of IGF1R from ODCs protected against clinical neuroinflammation in the EAE model. Together, our data indicate that IGF-1 signaling is not required for the function and survival of mature ODCs in steady-state and disease.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute |
UniBE Contributor: |
Locatelli, Giuseppe, Walthert, Sabrina |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0894-1491 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Andrea Stettler |
Date Deposited: |
11 Jan 2023 07:05 |
Last Modified: |
20 Mar 2023 15:57 |
Publisher DOI: |
10.1002/glia.24299 |
PubMed ID: |
36394300 |
Uncontrolled Keywords: |
EAE demyelination insulin-like growth factor 1 multiple sclerosis neuroinflammation oligodendrocyte |
BORIS DOI: |
10.48350/177182 |
URI: |
https://boris.unibe.ch/id/eprint/177182 |
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