Pattern Generation by Two Coupled Time-Discrete Neural Networks with Synaptic Depression

Senn, W.; Wannier, Th.; Kleinle, J.; Lüscher, H.-R.; Müller, L.; Streit, J.; Wyler, K. (1998). Pattern Generation by Two Coupled Time-Discrete Neural Networks with Synaptic Depression. Neural computation, 10(5), pp. 1251-1275. MIT Press 10.1162/089976698300017449

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Numerous animal behaviors, such as locomotion in vertebrates, are produced by rhythmic contractions that alternate between two muscle groups. The neuronal networks generating such alternate rhythmic activity are generally thought to rely on pacemaker cells or well-designed circuits consisting of inhibitory and excitatory neurons. However, experiments in organotypic cultures of embryonic rat spinal cord have shown that neuronal networks with purely excitatory and random connections may oscillate due to their synaptic depression, even without pacemaker cells. In this theoretical study, we investigate what happens if two such networks are symmetrically coupled by a small number of excitatory connections. We discuss a time-discrete mean-field model describing the average activity and the average synaptic depression of the two networks. Depending on the parameter values of the depression, the oscillations will be in phase, antiphase, quasiperiodic, or phase trapped. We put forward the hypothesis that pattern generators may rely on activity-dependent tuning of synaptic depression.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology
UniBE Contributor:	Senn, Walter, Lüscher, Hans-Rudolf, Streit, Jürg
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0899-7667
Publisher:	MIT Press
Language:	English
Submitter:	Virginie Sabado
Date Deposited:	18 Jan 2023 15:27
Last Modified:	18 Jan 2023 23:28
Publisher DOI:	10.1162/089976698300017449
PubMed ID:	9654770
URI:	https://boris.unibe.ch/id/eprint/177307