Pastore-Wapp, Manuela; Kaufmann, Brigitte C; Nyffeler, Thomas; Wapp, Simona; Bohlhalter, Stephan; Vanbellingen, Tim (2023). Feasibility of a combined intermittent theta-burst stimulation and video game-based dexterity training in Parkinson's disease. Journal of NeuroEngineering and Rehabilitation, 20(1), p. 2. BioMed Central 10.1186/s12984-023-01123-w
|
Text
s12984-023-01123-w.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (868kB) | Preview |
BACKGROUND
Persons with Parkinson's disease (PD) often exhibit difficulties with dexterity during the performance of activities of daily living (ADL), inter alia due to dysfunctional supplementary motor area (SMA). Combined intermittent theta-burst stimulation (iTBS) over the SMA followed by video game-based training (VBT) may therefore improve dexterity related ADL. The VBT may induce high flow levels related to high performance during the training. The aim of this study is to evaluate the feasibility of a combined iTBS-VBT intervention in persons with PD.
METHODS
A total of nine persons with PD (mean age 63.3 ± 8.76 years) with self-reported difficulties with dexterity related ADL were included in this pilot iTBS-VBT study. All participants received either iTBS or sham stimulation over the SMA followed by a 45-min VBT, three times a week for a total of three weeks. Feasibility was measured by means of the adherence rate and the system usability (System Usability Scale). Moreover, flow was measured after the last VBT session.
RESULTS
Adherence rate was excellent with 100%. High system usability scores (i.e., mean 80%, range 55-97.5) and a significant Spearman's correlation with the Flow State Scale (r = .762, p = .017) further point to the high feasibility of the VBT. Neither demographic variables nor difficulties in dexterity related ADL affected the usability of the VBT.
CONCLUSION
This study demonstrates the high feasibility of a combined iTBS-VBT intervention. Moreover, the level of self-reported usability was related to flow experience. Whether this kind of combined iTBS-VBT intervention improves dexterity will be evaluated in a randomized controlled trial. Trial registration clincaltrials.gov NCT04699149, date of registration 1. June 2021.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Pastore-Wapp, Manuela, Nyffeler, Thomas, Vanbellingen, Tim |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1743-0003 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 Jan 2023 07:47 |
Last Modified: |
19 Jan 2023 23:27 |
Publisher DOI: |
10.1186/s12984-023-01123-w |
PubMed ID: |
36635679 |
Uncontrolled Keywords: |
Dexterity Feasibility Intermittent theta-burst stimulation Parkinson’s disease Video game-based training |
BORIS DOI: |
10.48350/177353 |
URI: |
https://boris.unibe.ch/id/eprint/177353 |
Actions (login required)
 |
Edit item |