Mushtaq, Rao; Cortot, Alexis B; Gautschi, Oliver; Mazieres, Julien; Camidge, D Ross (2022). PD-1/PD-L1 inhibitor activity in patients with gene-rearrangement positive non-small cell lung cancer-an IMMUNOTARGET case series. Translational lung cancer research, 11(12), pp. 2412-2417. AME Publishing 10.21037/tlcr-22-329
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BACKGROUND
Prior IMMUNOTARGET registry data had suggested that responses to immune [anti PD(L)1] monotherapy in gene-arranged non-small cell lung cancer (NSCLC) were rare or absent, depending on the specific oncogene.
METHODS
IMMUNOTARGET sites reporting prior registry data or new individual cases of gene rearranged NSCLC seeming to benefit from immune monotherapy were explored in detail looking to both validate their diagnosis of a functional gene rearrangement and to look for features potentially differentiating them from other such cases associated with low response rates.
RESULTS
Five cases of NSCLC with a gene rearrangement with reported responses or prolonged stabilization from immune monotherapy were identified in total. All had little or no prior smoking history and had programmed death-ligand 1 (PD-L1) values ranging from zero to 100%. A confirmed rearrangement partner was reported in only 2 of the cases (CD74-ROS1 and KIF5B-RET), however in one of the other three cases [analplastic lymophoma kinase (ALK)], significant benefit from a relevant prior targeted therapy was noted, also consistent with the rearrangement status being correctly assigned.
CONCLUSIONS
Not all driver oncogene subtypes of NSCLC are equally responsive to immune monotherapy, however even among patients with well-validated gene rearranged NSCLC which has traditionally been considered immune hyporesponsive, objective responses can occur. Additional explorations of the features associated with and underlying the immune hypo-responsiveness of most, but not all, cases of gene-rearranged NSCLC are required.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Gautschi, Oliver |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2226-4477 |
Publisher: |
AME Publishing |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
17 Jan 2023 13:54 |
Last Modified: |
18 Jan 2023 04:40 |
Publisher DOI: |
10.21037/tlcr-22-329 |
PubMed ID: |
36636412 |
Uncontrolled Keywords: |
Anaplastic lymphoma kinase (ALK) Ros proto-oncogene-1 (ROS1) case series programmed cell death 1 (PD-1) programmed death-ligand 1 (PD-L1) rearranged during transfection (RET) |
BORIS DOI: |
10.48350/177395 |
URI: |
https://boris.unibe.ch/id/eprint/177395 |
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