Mattison, Lars; Verma, Atul; Tarakji, Khaldoun G; Reichlin, Tobias; Hindricks, Gerhard; Sack, Kevin L; Önal, Birce; Schmidt, Megan M; Miklavčič, Damijan; Sigg, Daniel C (2023). Effect of Contact Force on Pulsed Field Ablation Lesions in Porcine Cardiac Tissue. Journal of cardiovascular electrophysiology, 34(3), pp. 693-699. Wiley-Blackwell 10.1111/jce.15813
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Cardiovasc_electrophysiol_-_2023_-_Mattison_-_Effect_of_contact_force_on_pulsed_field_ablation_lesions_in_porcine_cardiac.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (820kB) | Preview |
BACKGROUND
Contact force has been used to titrate lesion formation for radiofrequency ablation. Pulsed Field Ablation (PFA) is a field-based ablation technology for which limited evidence on the impact of contact force on lesion size is available.
METHODS
Porcine hearts (n=6) were perfused using a modified Langendorff set-up. A prototype focal PFA catheter attached to a force gauge was held perpendicular to the epicardium and lowered until contact was made. Contact force was recorded during each PFA delivery. Matured lesions were cross-sectioned, stained, and the lesion dimensions measured.
RESULTS
A total of 82 lesions were evaluated with contact forces between 1.3 g and 48.6 g. Mean lesion depth was 4.8 ± 0.9 mm (standard deviation), mean lesion width was 9.1 ± 1.3 mm and mean lesion volume was 217.0. ± 96.6 mm3 . Linear regression curves showed an increase of only 0.01 mm in depth (Depth = 0.01*Contact Force + 4.41, R2 = 0.05), 0.03 mm in width (Width = 0.03*Contact Force + 8.26, R2 = 0.13) for each additional gram of contact force, and 2.20 mm3 in volume (Volume = 2.20*Contact Force + 162, R2 = 0.10).
CONCLUSIONS
Increasing contact force using a bipolar, biphasic focal PFA system has minimal effects on acute lesion dimensions in an isolated porcine heart model and achieving tissue contact is more important than the force with which that contact is made. This article is protected by copyright. All rights reserved.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Reichlin, Tobias Roman |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1045-3873 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
25 Jan 2023 14:20 |
Last Modified: |
11 Mar 2023 00:14 |
Publisher DOI: |
10.1111/jce.15813 |
PubMed ID: |
36640426 |
Uncontrolled Keywords: |
Cardiac ablation contact force irreversible electroporation pulsed field ablation |
BORIS DOI: |
10.48350/177403 |
URI: |
https://boris.unibe.ch/id/eprint/177403 |
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