Lesion size and long-term cognitive outcome after pediatric stroke: A comparison between two techniques to assess lesion size.

Everts, Regula; Bertato, Shana; Steinlin, Maja; Slavova, Nedelina; Grunt, Sebastian; Steiner, Leonie (2023). Lesion size and long-term cognitive outcome after pediatric stroke: A comparison between two techniques to assess lesion size. European journal of paediatric neurology, 42, pp. 126-132. Elsevier 10.1016/j.ejpn.2023.01.001

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BACKGROUND

There is little consensus on how lesion size impacts long-term cognitive outcome after pediatric arterial ischemic stroke (AIS). This study, therefore, compared two techniques to assessed lesion size in the chronic phase after AIS and determined their measurement agreement in relation to cognitive functions in patients after pediatric stroke.

METHODS

Twenty-five patients after pediatric AIS were examined in the chronic phase (>2 years after stroke) in respect to intelligence, memory, executive functions, visuo-motor functions, motor abilities, and disease-specific outcome. Lesion size was measured using the ABC/2 formula and segmentation technique (3D Slicer). Correlation analysis determined the association between volumetry techniques and outcome measures in respect to long-term cognitive outcome.

RESULTS

The measurements from the ABC/2 and segmentation technique were strongly correlated (r = 0.878, p < .001) and displayed agreement in particular for small lesions. Lesion size from both techniques was significantly correlated with disease-specific outcome (p < .001) and processing speed (p < .005) after controlling for age at stroke and multiple comparison.

CONCLUSION

The two techniques showed convergent validity and were both significantly correlated with long-term outcome after pediatric AIS. Compared to the time-consuming segmentation technique, ABC/2 facilitates clinical and research work as it requires relatively little time and is easy to apply.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Everts, Regula, Bertato, Shana Elina, Steinlin, Maja, Slavova, Nedelina Bozhidarova, Grunt, Sebastian, Steiner, Leonie Serena

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1090-3798

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

20 Jan 2023 11:15

Last Modified:

08 Jan 2024 14:32

Publisher DOI:

10.1016/j.ejpn.2023.01.001

PubMed ID:

36641854

Uncontrolled Keywords:

ABC/2 Cognitive outcome Lesion size Pediatric arterial ischemic stroke (AIS) Segmentation

BORIS DOI:

10.48350/177411

URI:

https://boris.unibe.ch/id/eprint/177411

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