Ho, Manh Tin; Berger, Stephan; Müller, Philipp; Simonin, Céline; Reymond, Jean-Louis; von Ballmoos, Christoph; Fuster, Daniel G. (21 December 2022). Physiological and Molecular Function of the Sodium/Hydrogen Exchanger NHA2 (SLC9B2). CHIMIA, 76(12), pp. 1019-1024. Swiss Chemical Society 10.2533/chimia.2022.1019
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NHA2, also known as SLC9B2, is an orphan intracellular Na+/H+ exchanger (NHE) that has been associated with arterial hypertension and diabetes mellitus in humans. The objective of this NCCR TransCure project was to define the physiological and molecular function of NHA2, to develop a high resolution kinetic transport assay for NHA2 and to identify specific and potent compounds targeting NHA2. In this review, we summarize the results of this highly interdisciplinary and interfaculty effort, led by the groups of Proffs. Jean-Louis Reymond, Christoph von Ballmoos and Daniel Fuster.
Item Type: |
Newspaper or Magazine Article |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension 08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Ho, Manh Tin, Berger, Stephan, Müller, Philipp Isaak, Simonin, Céline, Reymond, Jean-Louis, von Ballmoos, Christoph, Fuster, Daniel Guido |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry 600 Technology > 610 Medicine & health |
ISSN: |
0009-4293 |
Publisher: |
Swiss Chemical Society |
Language: |
English |
Submitter: |
Sandra Tanja Zbinden Di Biase |
Date Deposited: |
23 Jan 2023 11:20 |
Last Modified: |
23 Jan 2023 23:28 |
Publisher DOI: |
10.2533/chimia.2022.1019 |
BORIS DOI: |
10.48350/177638 |
URI: |
https://boris.unibe.ch/id/eprint/177638 |
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