Wertli, M M; Rossi, D; Burgstaller, J M; Held, U; Ulrich, N H; Farshad, M; Steurer, J; Brunner, F (2023). Validity of outcome measures used in randomized clinical trials and observational studies in degenerative lumbar spinal stenosis. Scientific reports, 13(1), p. 1068. Springer Nature 10.1038/s41598-022-27218-3
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It is unclear whether outcome measures used in degenerative lumbar spinal stenosis (DLSS) have been validated for this condition. Cross-sectional analysis of studies for DLSS included in systematic reviews (SA) and meta-analyses (MA) indexed in the Cochrane Library. We extracted all outcome measures for pain and disability. We assessed whether the studies provided external references for the validity of the outcome measures and the quality of the validation studies. Out of 20 SA/MA, 95 primary studies used 242 outcome measures for pain and/or disability. Most commonly used were the VAS (n = 69), the Oswestry Disability Index (n = 53) and the Zurich Claudication Questionnaire (n = 22). Although validation references were provided in 45 (47.3%) primary studies, only 14 validation studies for 9 measures (disability n = 7, pain and disability combined n = 2) were specifically validated in a DLSS population. The quality of the validation studies was mainly poor. The Zurich Claudication Questionnaire was the only disease specific tool with adequate validation for assessing treatment response in DLSS. To compare results from clinical studies, outcome measures need to be validated in a disease specific population. The quality of validation studies need to be improved and the validity in studies adequately cited.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine |
UniBE Contributor: |
Wertli, Maria Monika |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
23 Jan 2023 13:44 |
Last Modified: |
05 Feb 2023 02:25 |
Publisher DOI: |
10.1038/s41598-022-27218-3 |
PubMed ID: |
36658179 |
BORIS DOI: |
10.48350/177699 |
URI: |
https://boris.unibe.ch/id/eprint/177699 |
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