Dirchwolf, Melisa; Becchetti, Chiara; Stampf, Susanne; Haldimann, Christa; Immer, Franz; Beyeler, Franziska; Toso, Christian; Dutkowski, Philipp; Candinas, Daniel; Dufour, Jean-Francois; Banz, Vanessa (2023). The impact of perceived donor liver quality on post-transplant outcome. ANZ journal of surgery, 93(4), pp. 918-925. Wiley 10.1111/ans.18217
|
Text
ANZ_Journal_of_Surgery_-_2023_-_Dirchwolf_-_The_impact_of_perceived_donor_liver_quality_on_post_transplant_outcome.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (560kB) | Preview |
BACKGROUND
We analysed the impact of perceived liver donor quality on transplant recipient outcomes.
METHODS
this prospective cohort study included all deceased liver donors during 2008-2018 in the Swiss Transplant Cohort Study. Perceived low-quality liver donors were defined when refused for ≥5 top listed recipients or for all recipients in at least one centre before being transplanted. The effect of liver donor quality on relisting or recipient death at 1 week and 1 year after transplantation was analysed using Kaplan-Meier and Cox proportional hazard models. A 1:3 matching was also performed using a recipient score.
RESULTS
Of 973 liver donors, 187 (19.2%) had perceived poor-quality. Males, obesity, donation after circulatory death and alanine aminotransferase values were significantly associated with perceived poor-quality, with no significant effect of the perceived quality on re-listing or death within the first week and first year post-transplant [(aHR) = 1.45, 95% CI: (0.6, 3.5), P = 0.41 and aHR = 1.52 (95% CI 0.98-2.35), P = 0.06], adjusting by recipient age and gender, obesity, diabetes, prior liver transplantation and model for end-stage liver disease (MELD) score. At 1 year, prior liver transplantation and higher MELD score associated with higher risk of re-listing or death.
CONCLUSION
Comparable post-transplant outcomes with different perceived quality liver donors stresses the need to improve donor selection in liver transplantation.
Actions (login required)
 |
Edit item |