Mastropierro, Pasquale; Kennedy, Alan R.; Hevia, Eva (2022). Metallation of sensitive fluoroarenes using a potassium TMP-zincate supported by a silyl(bis)amido ligand. Chemical Communications, 58(34), pp. 5292-5295. Royal Society of Chemistry 10.1039/D2CC00979J
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Combining a bulky bis(amide) and a reactive one-coordinate TMP (2,2,6,6-tetramethylpiperidide) ligand, a new mixed K/Zn heteroleptic base has been developed for regioselective zincation of fluoroarenes. This special ligand set allows for trapping and structural authentication of the first intermediates of direct Zn-H exchange of fluoroarenes obtained via deprotonative metallation, providing mechanistic insights of the processes involved.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Mastropierro, Pasquale, Hevia Freire, Eva |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry 000 Computer science, knowledge & systems |
ISSN: |
1359-7345 |
Publisher: |
Royal Society of Chemistry |
Language: |
English |
Submitter: |
Franziska Bornhauser-Rufer |
Date Deposited: |
08 Feb 2023 11:54 |
Last Modified: |
09 Feb 2023 21:34 |
Publisher DOI: |
10.1039/D2CC00979J |
PubMed ID: |
35403647 |
BORIS DOI: |
10.48350/178529 |
URI: |
https://boris.unibe.ch/id/eprint/178529 |
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