Quezada-Pinedo, Hugo G; Jaddoe, Vincent; Duijts, Liesbeth; Muka, Taulant; Vermeulen, Marijn J; Reiss, Irwin K M; Santos, Susana (2023). Maternal iron status in early pregnancy and childhood body fat measures and cardiometabolic risk factors: A population-based prospective cohort. American journal of clinical nutrition, 117(1), pp. 191-198. American Society for Nutrition, Inc. 10.1016/j.ajcnut.2022.10.006
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BACKGROUND
Whether maternal iron status during pregnancy is associated with cardiometabolic health in the offspring is poorly known.
OBJECTIVES
We aimed to assess the associations of maternal iron status during early pregnancy with body fat measures and cardiometabolic risk factors in children aged 10 y.
METHODS
In a population-based cohort study among 3718 mother-child pairs, we measured ferritin, transferrin, and transferrin saturation during early pregnancy. We obtained child BMI, fat mass index, and android/gynoid fat mass ratio by DXA, subcutaneous fat index, visceral fat index, pericardial fat index, and liver fat fraction by magnetic resonance imaging and assessed systolic and diastolic blood pressure, serum lipids, glucose, insulin, and CRP at 10 y.
RESULTS
A one-standard deviation score (SDS) higher maternal ferritin was associated with lower fat mass index [difference -0.05 (95% CI: -0.08, -0.02) SDS] and subcutaneous fat index [difference -0.06 (95% CI: -0.10, -0.02) SDS] in children. One-SDS higher maternal transferrin was associated with higher fat mass index [difference 0.04 (95% CI: 0.01, 0.07) SDS], android/gynoid fat mass ratio [difference 0.05 (95% CI: 0.02, 0.08) SDS], and subcutaneous fat index [difference 0.06 (95% CI: 0.02, 0.10) SDS] in children. Iron status during pregnancy was not consistently associated with organ fat and cardiometabolic risk factors at 10 y.
CONCLUSIONS
Maternal lower ferritin and higher transferrin in early pregnancy are associated with body fat accumulation and distribution but are not associated with cardiometabolic risk factors in childhood. Underlying mechanisms and long-term consequences warrant further study.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Muka, Taulant |
ISSN: |
0002-9165 |
Publisher: |
American Society for Nutrition, Inc. |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
16 Feb 2023 13:18 |
Last Modified: |
17 Dec 2023 00:25 |
Publisher DOI: |
10.1016/j.ajcnut.2022.10.006 |
PubMed ID: |
36789938 |
Uncontrolled Keywords: |
cardiometabolic health cohort studies fetal programing iron pregnancy |
BORIS DOI: |
10.48350/178865 |
URI: |
https://boris.unibe.ch/id/eprint/178865 |
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