Charalambous, Marios; Fischer, Andrea; Potschka, Heidrun; Walker, Matthew C; Raedt, Robrecht; Vonck, Kristl; Boon, Paul; Lohi, Hannes; Löscher, Wolfgang; Worrell, Gregory; Leeb, Tosso; McEvoy, Andrew; Striano, Pasquale; Kluger, Gerard; Galanopoulou, Aristea S; Volk, Holger A; Bhatti, Sofie F M (2023). Translational veterinary epilepsy: A win-win situation for human and veterinary neurology. Veterinary journal, 293(105956), p. 105956. Elsevier 10.1016/j.tvjl.2023.105956
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Epilepsy is a challenging multifactorial disorder with a complex genetic background. Our current understanding of the pathophysiology and treatment of epilepsy has substantially increased due to animal model studies, including canine studies, but additional basic and clinical research is required. Drug-resistant epilepsy is an important problem in both dogs and humans, since seizure freedom is not achieved with the available antiseizure medications. The evaluation and exploration of pharmacological and particularly non-pharmacological therapeutic options need to remain a priority in epilepsy research. Combined efforts and sharing knowledge and expertise between human medical and veterinary neurologists are important for improving the treatment outcomes or even curing epilepsy in dogs. Such interactions could offer an exciting approach to translate the knowledge gained from people and rodents to dogs and vice versa. In this article, a panel of experts discusses the similarities and knowledge gaps in human and animal epileptology, with the aim of establishing a common framework and the basis for future translational epilepsy research.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics |
UniBE Contributor: |
Leeb, Tosso |
Subjects: |
500 Science > 590 Animals (Zoology) 600 Technology > 630 Agriculture |
ISSN: |
1090-0233 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
16 Feb 2023 12:17 |
Last Modified: |
14 Feb 2024 00:25 |
Publisher DOI: |
10.1016/j.tvjl.2023.105956 |
PubMed ID: |
36791876 |
Uncontrolled Keywords: |
Dog Human Nervous system Seizures Therapy |
BORIS DOI: |
10.48350/178875 |
URI: |
https://boris.unibe.ch/id/eprint/178875 |
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