Grychtol, Ruth; Riemann, Lennart; Gaedcke, Svenja; Liu, Bin; DeLuca, David; Förster, Reinhold; Maison, Nicole; Thiele, Dominik; Jakobs, Nikolas; Bahmer, Thomas; Meyer, Meike; Foth, Svenja; Weber, Stefanie; Rietschel, Ernst; Rabe, Klaus F; Kopp, Matthias V; von Mutius, Erika; Dittrich, Anna-Maria; Hansen, Gesine (2023). Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE cohort. The Journal of allergy and clinical immunology, 151(6), 1525-1535.e4. Elsevier 10.1016/j.jaci.2023.01.027
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BACKGROUND
The Asthma Severity Scoring System (ASSESS) quantifies asthma severity in adolescents and adults. Scale performance in children < 12 years is unknown.
OBJECTIVE
To validate the ASSESS score in the All Age Asthma Cohort (ALLIANCE) and explore its use in children <12 years.
METHODS
Scale properties, responsiveness, and known-group validity were assessed in 247 children (median age 11 years, IQR: 8-13 years) and 206 adults (median age 52 years, IQR: 43-63 years).
RESULTS
Overall, measures of internal test consistency and test-retest reliability were similar to the original data of the Severe Asthma Research Program (SARP). Cronbach's α was 0.59 in children 12-18 years and 0.73 in adults, reflecting the inclusion of multiple and not always congruent dimensions to the ASSESS score especially in children. Analysis of known-group validity confirmed the discriminatory power, as the ASSESS score was significantly worse in patients with poor asthma control, exacerbations and increased salbutamol use. In children between 6-11 years test reliability was inferior compared to adults and adolescents (Cronbach's α 0.27) mostly due to a less lung function impairment in asthmatic children of this age group. Known-group validity however confirmed good discriminative power regarding severity-associated variables similar to adolescents and adults.
CONCLUSION
Test reliability and validity of the ASSESS score was confirmed in the ALLIANCE cohort. In children aged 6-11 years internal consistency was inferior compared to older asthma patients, however test validity was good and encourages age-spanning usage of the ASSESS score in all asthma patients ≥ 6 years.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology |
UniBE Contributor: |
Kopp, Matthias Volkmar |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1097-6825 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
23 Feb 2023 14:57 |
Last Modified: |
16 Feb 2024 00:25 |
Publisher DOI: |
10.1016/j.jaci.2023.01.027 |
PubMed ID: |
36804993 |
Uncontrolled Keywords: |
ALLIANCE Adult asthma Asthma Asthma control Asthma severity Children Pediatric asthma Validation study |
BORIS DOI: |
10.48350/179065 |
URI: |
https://boris.unibe.ch/id/eprint/179065 |
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