Pawlak, Paulina; Burren, Alexander; Seitz, Andreas; Pietsch, Constanze (2023). Effects of different acute stressors on the regulation of appetite genes in the carp (Cyprinus carpio L.) brain. Royal Society Open Science, 10(2), p. 230040. The Royal Society Publishing 10.1098/rsos.230040
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Our understanding of the timing of stress responses and specific roles of different regulatory pathways that drive stress responses is incomplete. In particular, the regulation of appetite genes as a consequence of exposure to different stressors has not been studied in sufficient detail in fish. Therefore, a stress trial was conducted with koi carp, aiming at identifying typical effects of stress on regulation of appetite genes. The stressors tank manipulation, air exposure and feed rewarding were chosen. The responses to these stressors were evaluated 10, 30 and 60 min after the stressors were applied. Orexigenic and anorexigenic genes were investigated in four different brain regions (telencephalon, hypothalamus, optic tectum and rhombencephalon). The results show that, apart from the typical appetite regulation in the hypothalamus, the different brain regions also display pronounced responses of appetite genes to the different stressors. In addition, several genes in the serotonergic, dopaminergic and gaba-related pathways were investigated. These genes revealed that rearing in pairs of two and opening of the tank lid affected anorexigenic genes, such as cart and cck, which were not changed by air exposure or feed rewarding. Moreover, distress and eustress led to limited, but distinguishable gene expression pattern changes in the investigated brain regions.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Ecology and Evolution (IEE) |
ISSN: |
2054-5703 |
Publisher: |
The Royal Society Publishing |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
02 Mar 2023 10:09 |
Last Modified: |
05 Mar 2023 02:18 |
Publisher DOI: |
10.1098/rsos.230040 |
PubMed ID: |
36816841 |
Uncontrolled Keywords: |
appetite regulation aquaculture feeding behaviour gene expression regulation stressors |
BORIS DOI: |
10.48350/179167 |
URI: |
https://boris.unibe.ch/id/eprint/179167 |
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