Impact of fixed orthodontic appliances on blood count and high-sensitivity C-reactive protein levels: A prospective cohort study.

Kloukos, Dimitrios; Kalimeri, Eleni; Gkourtsogianni, Sofia; Kantarci, Alpdogan; Katsaros, Christos; Stavropoulos, Andreas (2023). Impact of fixed orthodontic appliances on blood count and high-sensitivity C-reactive protein levels: A prospective cohort study. American journal of orthodontics and dentofacial orthopedics, 164(3), pp. 351-356. Elsevier 10.1016/j.ajodo.2023.01.016

[img]
Preview
Text
1-s2.0-S0889540623001075-main.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (294kB) | Preview

INTRODUCTION

The aim was to elucidate the magnitude of alterations in systemic blood counts in healthy patients during the first 14 days after fixed orthodontic appliance placement.

METHODS

This prospective cohort study consecutively included 35 White Caucasian patients starting orthodontic treatment with fixed appliances. The mean age was 24.48 ± 6.68 years. All patients were physically and periodontally healthy. Blood samples were collected at 3 time points: (1) baseline (exactly before the placement of appliances), (2) 5 days after bonding, and (3) 14 days after baseline. Whole blood and erythrocyte sedimentation rates were analyzed in automated hematology and erythrocyte sedimentation rate analyzer. Serum high-sensitivity C-reactive protein levels were measured by the nephelometric method. Standardized sample handling and patient preparation procedures were adopted to reduce preanalytical variability.

RESULTS

A total of 105 samples were analyzed. All clinical and orthodontic procedures were performed without complications or side effects during the study period. All laboratory procedures were performed per protocol. Significantly lower white blood cell counts were detected 5 days after bracket bonding, compared with baseline (P <0.05). Hemoglobin levels were lower at 14 days than baseline (P <0.05). No other significant shifts or alteration patterns were observed over time.

CONCLUSIONS

Orthodontic fixed appliances led to a limited and transient change in white blood cell counts and hemoglobin levels during the first days after bracket placement. The fluctuation of high-sensitivity C-reactive protein levels was not significant, demonstrating a lack of association between systemic inflammation and orthodontic treatment.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics

UniBE Contributor:

Kloukos, Dimitrios (B), Katsaros, Christos

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1097-6752

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

21 Mar 2023 12:16

Last Modified:

29 Aug 2023 00:12

Publisher DOI:

10.1016/j.ajodo.2023.01.016

PubMed ID:

36941188

BORIS DOI:

10.48350/180400

URI:

https://boris.unibe.ch/id/eprint/180400

Actions (login required)

Edit item Edit item
Provide Feedback