Gebremedhin, Amanuel T; Mitter, Vera R; Duko, Bereket; Tessema, Gizachew A; Pereira, Gavin F (2024). Associations between endometriosis and adverse pregnancy and perinatal outcomes: a population-based cohort study. Archives of gynecology and obstetrics, 309(4), pp. 1323-1331. Springer 10.1007/s00404-023-07002-y
|
Text
s00404-023-07002-y.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (700kB) | Preview |
PURPOSE
To examine the association between endometriosis and adverse pregnancy and perinatal outcomes (preeclampsia, placenta previa, and preterm birth).
METHODS
A population-based retrospective cohort study was conducted among 468,778 eligible women who contributed 912,747 singleton livebirths between 1980 and 2015 in Western Australia (WA). We used probabilistically linked perinatal and hospital separation data from the WA data linkage system's Midwives Notification System and Hospital Morbidity Data Collection databases. We used a doubly robust estimator by combining the inverse probability weighting with the outcome regression model to estimate adjusted risk ratios (RR) and 95% confidence intervals (CIs).
RESULTS
There were 19,476 singleton livebirths among 8874 women diagnosed with endometriosis. Using a doubly robust estimator, we found pregnancies in women with endometriosis to be associated with an increased risk of preeclampsia with RR of 1.18, 95% CI 1.11-1.26, placenta previa (RR 1.59, 95% CI 1.42-1.79) and preterm birth (RR 1.45, 95% CI 1.37-1.54). The observed association persisted after stratified by the use of Medically Assisted Reproduction, with a slightly elevated risk among pregnancies conceived spontaneously.
CONCLUSIONS
In this large population-based cohort, endometriosis is associated with an increased risk of preeclampsia, placenta previa, and preterm birth, independent of the use of Medically Assisted Reproduction. This may help to enhance future obstetric care among this population.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
Mitter, Vera Ruth |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-0711 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 Mar 2023 09:43 |
Last Modified: |
26 Feb 2024 00:11 |
Publisher DOI: |
10.1007/s00404-023-07002-y |
PubMed ID: |
36939861 |
Uncontrolled Keywords: |
Endometriosis Medically assisted reproduction Placenta previa Preeclampsia Preterm birth |
BORIS DOI: |
10.48350/180404 |
URI: |
https://boris.unibe.ch/id/eprint/180404 |
Actions (login required)
 |
Edit item |