Stangl, Fabian P; Godly, Julia; Kranz, Jennifer; Neumann, Thomas; Schneidewind, Laila (2023). [Do we need to treat asymptomatic bacteriuria in immunocompromised patients? : A rapid review]. Die Urologie, 62(6), pp. 609-614. Springer 10.1007/s00120-023-02059-8
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BACKGROUND
Antimicrobial resistance (AMR), especially multidrug resistant Escherichia coli strains, is a problem even in Europe. That is why inadequate usage of antibiotic therapy should be avoided, especially in the treatment of asymptomatic bacteriuria (ASB).
OBJECTIVES
Should ASB be treated with antibiotics in immunocompromized patients, namely solid organ transplant, especially kidney transplant or stem cell transplant recipients?
MATERIALS AND METHODS
A rapid review based on a systematic literature search in MEDLINE between 1980 and 2022 was performed. For evidence synthesis, only randomized controlled trials (RCTs) or quasi-RCTs were considered.
RESULTS
No studies were identified for the search term solid organ and stem cell transplantation. Three RCTs (antibiotic therapy versus no therapy) were included for adult kidney transplantation. None of the studies showed a benefit for antibiotic therapy of ASB in reduction of symptomatic urinary tract infections, especially in the late transplantation phase two months after kidney transplantation; furthermore, this therapy may promote AMR development. In addition, there are numerous gaps of evidence, e.g., in pediatric transplantation or regarding the influence of special immunosuppressants.
CONCLUSION
There is no evidence for antibiotic therapy of ASB in adult kidney transplantation two months after the surgery. Further studies addressing the identified evidence gaps are essential for the prevention of further AMR development.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology |
UniBE Contributor: |
Stangl, Fabian Peter |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2731-7072 |
Publisher: |
Springer |
Language: |
German |
Submitter: |
Pubmed Import |
Date Deposited: |
22 Mar 2023 10:54 |
Last Modified: |
07 Jun 2023 00:13 |
Publisher DOI: |
10.1007/s00120-023-02059-8 |
PubMed ID: |
36941381 |
Uncontrolled Keywords: |
Antimicrobial stewardship Asymptomatic bacteriuria Immunosuppression Infections in urology Transplantation |
BORIS DOI: |
10.48350/180470 |
URI: |
https://boris.unibe.ch/id/eprint/180470 |
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