Association between circadian sleep regulation and cortical gyrification in young and older adults.

Deantoni, Michele; Reyt, Mathilde; Berthomier, Christian; Muto, Vincenzo; Hammad, Gregory; De Haan, Stella; Dourte, Marine; Taillard, Jacques; Lambot, Eric; Cajochen, Christian; Reichert, Carolin F; Maire, Micheline; Baillet, Marion; Schmidt, Christina (2023). Association between circadian sleep regulation and cortical gyrification in young and older adults. Sleep, 46(9), zsad094. American Academy of Sleep Medicine 10.1093/sleep/zsad094

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The circadian system orchestrates sleep timing and structure and is altered with increasing age. Sleep propensity, and particularly REM sleep is under strong circadian control and has been suggested to play an important role in brain plasticity. In this exploratory study, we assessed whether surface-based brain morphometry indices are associated with circadian sleep regulation and whether this link changes with age. Twenty-nine healthy older (55-82 years; 16 men) and 28 young participants (20-32 years; 13 men) underwent both structural magnetic resonance imaging and a 40-h multiple nap protocol to extract sleep parameters over day and night time. Cortical thickness and gyrification indices were estimated from T1-weighted images acquired during a classical waking day. We observed that REM sleep was significantly modulated over the 24-h cycle in both age groups, with older adults exhibiting an overall reduction in REM sleep modulation compared to young individuals. Interestingly, when taking into account the observed overall age-related reduction in REM sleep throughout the circadian cycle, higher day-night differences in REM sleep were associated with increased cortical gyrification in the right inferior frontal and paracentral regions in older adults. Our results suggest that a more distinctive allocation of REM sleep over the 24-h cycle is associated with regional cortical gyrification in aging, and thereby point towards a protective role of circadian REM sleep regulation for age-related changes in brain organization.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)

UniBE Contributor:

Maire, Micheline Célia Dina

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0161-8105

Publisher:

American Academy of Sleep Medicine

Language:

English

Submitter:

Pubmed Import

Date Deposited:

04 Apr 2023 09:11

Last Modified:

04 Apr 2024 00:25

Publisher DOI:

10.1093/sleep/zsad094

PubMed ID:

37010079

Uncontrolled Keywords:

Brain Aging Circadian rhythm Cortical thickness Gyrification REM sleep Sleep

BORIS DOI:

10.48350/181477

URI:

https://boris.unibe.ch/id/eprint/181477

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