Outcomes of a radiation sparing approach in medulloblastoma by subgroup in young children: an institutional review.

Ronsley, Rebecca; Triscott, Joanna; Stanek, Joseph; Rassekh, S Rod; Lum, Amy; Cheng, Sylvia; Goddard, Karen; McConnell, Dina; Strahlendorf, Caron; Singhal, Ash; Finlay, Jonathan L; Yip, Stephen; Dunham, Christopher; Hukin, Juliette (2023). Outcomes of a radiation sparing approach in medulloblastoma by subgroup in young children: an institutional review. Child's nervous system, 39(8), pp. 2095-2104. Springer 10.1007/s00381-023-05918-z

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OBJECTIVE

To describe disease outcomes including overall survival and relapse patterns by subgroup in young pediatric patients treated for medulloblastoma with a radiation-sparing approach.

METHODS

Retrospective analysis of clinical outcomes includes treatment, relapse, and salvage therapy and late effects in children treated for medulloblastoma with a radiation-sparing approach at British Columbia Children's Hospital (BCCH) between 2000 and 2020.

RESULTS

There were 30 patients (median age 2.8 years, 60% male) treated for medulloblastoma with a radiation-sparing approach at BCCH. Subgroups included Sonic Hedgehog (SHH) (n = 14), group 3 (n = 7), group 4 (n = 6), and indeterminate status (n = 3). Three- and 5-year event-free survival (EFS) were 49.0% (30.2-65.4%) and 42.0% (24.2-58.9%) and overall survival (OS) 66.0% (95% CI 46.0-80.1%) and 62.5% (95% CI 42.5 and 77.2%), respectively, with a median follow-up of 9.5 years. Relapse occurred in 12/25 patients following a complete response, of whom six (group 4: n = 4; group 3: n = 1; unknown: n = 1) were successfully salvaged with craniospinal axis (CSA) RT and remain alive at a median follow-up of 7 years. Disease/treatment-related morbidity included endocrinopathies (n = 8), hearing loss n = 16), and neurocognitive abnormalities (n = 9).

CONCLUSIONS

This radiation sparing treatment approach for young patients with medulloblastoma resulted in a durable cure in most patients with SHH subgroup medulloblastoma. In those patients with groups 3 and 4 medulloblastoma, relapse rates were high; however, most group 4 patients were salvaged with RT.

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