A Case of Adult-Onset Kawasaki Disease in an Adolescent Occurring during the COVID-19 Pandemic

Aebi, Christoph; Schöbi, Nina; Duppenthaler, Andrea; Kopp, Matthias V.; Glöckler, Martin; Agyeman, Philipp K. A. (2023). A Case of Adult-Onset Kawasaki Disease in an Adolescent Occurring during the COVID-19 Pandemic. Journal of pediatric infectious diseases, 18(02), pp. 107-112. Georg Thieme Verlag 10.1055/s-0042-1758055

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We report the occurrence of the adult-onset type of Kawasaki disease (KD) with classic mucocutaneous manifestations of KD, cholestatic liver disease, multiple splenic infarcts, and residual multiple coronary artery dilatations in a previously healthy 14-year-old male adolescent 16 days after having received one dose of the BNT162b2 coronavirus disease 2019 (COVID-19) mRNA vaccine. First, the report serves to highlight the diagnostic challenges of adult-onset KD often resulting in therapeutic delay and the frequently reported occurrence of persistent cardiovascular sequelae. Second, the report emphasizes that the temporal association of KD with the administration of a COVID-19 vaccine will likely be a frequent constellation in the near future, raising questions of a causative association. While there is currently no evidence of such an association in persons above 5 years of age, large-scale vaccination of children below 5 years of age will require close surveillance of vaccine-related adverse events.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Infectiology

UniBE Contributor:

Aebi, Christoph, Schöbi, Nina, Duppenthaler, Andrea, Kopp, Matthias Volkmar, Glöckler, Martin, Agyeman, Philipp Kwame Abayie

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1305-7707

Publisher:

Georg Thieme Verlag

Language:

English

Submitter:

Christoph Aebi

Date Deposited:

11 Apr 2023 10:25

Last Modified:

08 Jun 2023 12:56

Publisher DOI:

10.1055/s-0042-1758055

BORIS DOI:

10.48350/181601

URI:

https://boris.unibe.ch/id/eprint/181601

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