Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression.

Denier, Niklaus; Walther, Sebastian; Breit, Sigrid; Mertse, Nicolas; Federspiel, Andrea; Meyer, Agnes; Soravia, Leila M; Wallimann, Meret; Wiest, Roland; Bracht, Tobias (2023). Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression. NeuroImage: Clinical, 38, p. 103404. Elsevier 10.1016/j.nicl.2023.103404

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Electroconvulsive therapy (ECT) is a highly efficient treatment for depression. Previous studies repeatedly reported an ECT-induced volume increase in the hippocampi. We assume that this also affects extended hippocampal networks. This study aims to investigate the structural and functional interplay between hippocampi, hippocampal pathways and core regions of the default mode network (DMN). Twenty patients with a current depressive episode receiving ECT-treatment and twenty age and sex matched healthy controls (HC) were included in the study. ECT-patients underwent multimodal magnetic resonance imaging (MRI)-scans (diffusion weighted imaging, resting state functional MRI) before and after an ECT-index series. HC were also scanned twice in a similar between-scan time-interval. Parahippocampal cingulum (PHC) and uncinate fasciculus (UF) were reconstructed for each participant using manual tractography. Fractional anisotropy (FA) was averaged across tracts. Furthermore, we investigated seed-based functional connectivity (FC) from bilateral hippocampi and from the PCC, a core region of the DMN. At baseline, FA in PHC and UF did not differ between groups. There was no baseline group difference of hippocampal-FC. PCC-FC was decreased in ECT-patients. ECT induced a decrease in FA in the left PHC in the ECT group. No longitudinal changes of FA were found in the UF. Furthermore, there was a decrease in hippocampal-PCC-FC, an increase in hippocampal-supplementary motor area-FC, and an increase in PCC-FC in the ECT-group, reversing group differences at baseline. Our findings suggest that ECT induces structural and functional remodeling of a hippocampal-DMN. Those changes may contribute to ECT-induced clinical response in patients with depression.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy

UniBE Contributor:

Denier, Niklaus, Walther, Sebastian, Breit, Sigrid, Federspiel, Andrea, Meyer, Agnes, Soravia, Leila, Wiest, Roland Gerhard Rudi, Bracht, Tobias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2213-1582

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

18 Apr 2023 09:46

Last Modified:

17 Jun 2023 00:14

Publisher DOI:

10.1016/j.nicl.2023.103404

PubMed ID:

37068311

Uncontrolled Keywords:

ECT Hippocampus Resting state functional connectivity Uncinate fasciculus, parahippocampal cingulum, posterior cingulate cortex White matter

BORIS DOI:

10.48350/181802

URI:

https://boris.unibe.ch/id/eprint/181802

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