Kriegmair, Valentin; Sigrist, Christine; Vöckel, Jasper; Kaess, Michael; Koenig, Julian (2023). Red Cell Distribution Width and Depressive Symptoms: A Failed Replication in Female Adolescents. The world journal of biological psychiatry, 24(8), pp. 754-759. Taylor & Francis 10.1080/15622975.2023.2203222
Full text not available from this repository.OBJECTIVES
Despite the increasingly high prevalence and serious consequences of depression in adolescents, there is a lack of economical and reliable biomarkers to aid the diagnostic process. Recent findings suggest that red blood cell distribution width (RDW) is an easily obtainable biomarker of depression in adults. Here, we aimed to replicate the finding of increased RDW in clinically depressed adolescents.
METHODS
Data from depressed adolescent female patients (n = 93) and healthy controls (HC) (n = 43) aged 12-17 years from the AtR!Sk-bio cohort study were retrospectively analyzed. We compared RDW between groups and tested whether there was an association between RDW and depression severity and global (psychiatric) symptom severity. We also examined the influence of age on RDW.
RESULTS
There was no significant difference between depressed patients and healthy controls and no association between RDW and depression severity. However, higher RDW values were associated with greater global symptom severity. Regardless of group, there was a positive association between RDW and age.
CONCLUSIONS
RDW appears to be unfit as an aid for clinical diagnosis of depression in adolescents, but may be useful in assessing global psychiatric symptom burden.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy |
UniBE Contributor: |
Kaess, Michael, Koenig, Julian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1814-1412 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 Apr 2023 09:39 |
Last Modified: |
05 Oct 2023 00:12 |
Publisher DOI: |
10.1080/15622975.2023.2203222 |
PubMed ID: |
37070471 |
Uncontrolled Keywords: |
Adolescents Biomarker Depression Red Cell Distribution Width |
URI: |
https://boris.unibe.ch/id/eprint/181837 |
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