Tennilä, Jussi; Jääskeläinen, Jarmo; Utriainen, Pauliina; Voutilainen, Raimo; Laitinen, Tomi; Liimatta, Jani (2023). Cardiorespiratory Fitness in Young Adult Women With a History of Premature Adrenarche. Journal of the Endocrine Society, 7(5), bvad041. Oxford University Press 10.1210/jendso/bvad041
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CONTEXT
Premature adrenarche (PA) may predispose to some adverse long-term health outcomes. Cardiorespiratory fitness (CRF) is one of the strongest factors known to predict overall health, but no data exist on the CRF of women with a history of PA.
OBJECTIVE
To study if hyperandrogenism in childhood resulting from PA leads to a measurable difference in CRF between young adult PA and control women.
METHODS
A total of 25 women with PA and 36 age-matched controls were followed from prepubertal age until adulthood. Anthropometric measurements, body composition, biochemical, and lifestyle factors were assessed. The main outcome measure was maximal cycle ergometer test result at the mean age of 18.5 years. We also assessed prepubertal predicting factors for CRF with different linear regression models.
RESULTS
Though prepubertal children with PA were taller and heavier than their non-PA peers, there were no significant differences in height, body mass index, body composition, or physical activity in young adulthood. We observed no significant differences in any of the parameters of the maximal cycle ergometer test, including maximal load (P = .194) or peak oxygen consumption (P = .340). Hemodynamic responses of the groups were similar. None of the examined models or prepubertal factors significantly predicted CRF at adult age.
CONCLUSION
This study suggests that hyperandrogenism in childhood/adolescence resulting from PA does not have a significant impact on adulthood CRF.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) |
UniBE Contributor: |
Liimatta, Jani Petri Tapani |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2472-1972 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 Apr 2023 13:02 |
Last Modified: |
23 Apr 2023 02:21 |
Publisher DOI: |
10.1210/jendso/bvad041 |
PubMed ID: |
37077523 |
Uncontrolled Keywords: |
cardiorespiratory fitness ergometer performance premature adrenarche |
BORIS DOI: |
10.48350/181876 |
URI: |
https://boris.unibe.ch/id/eprint/181876 |
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