Hopman, Luuk H G A; Hillier, Elizabeth; Liu, Yuchi; Hamilton, Jesse; Fischer, Kady; Seiberlich, Nicole; Friedrich, Matthias G (2023). Dynamic Cardiac Magnetic Resonance Fingerprinting During Vasoactive Breathing Maneuvers: First Results. Journal of cardiovascular imaging, 31(2), pp. 71-82. Korean Society of Echocardiography 10.4250/jcvi.2022.0080
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BACKGROUND
Cardiac magnetic resonance fingerprinting (cMRF) enables simultaneous mapping of myocardial T1 and T2 with very short acquisition times. Breathing maneuvers have been utilized as a vasoactive stress test to dynamically characterize myocardial tissue in vivo. We tested the feasibility of sequential, rapid cMRF acquisitions during breathing maneuvers to quantify myocardial T1 and T2 changes.
METHODS
We measured T1 and T2 values using conventional T1 and T2-mapping techniques (modified look locker inversion [MOLLI] and T2-prepared balanced-steady state free precession), and a 15 heartbeat (15-hb) and rapid 5-hb cMRF sequence in a phantom and in 9 healthy volunteers. The cMRF5-hb sequence was also used to dynamically assess T1 and T2 changes over the course of a vasoactive combined breathing maneuver.
RESULTS
In healthy volunteers, the mean myocardial T1 of the different mapping methodologies were: MOLLI 1,224 ± 81 ms, cMRF15-hb 1,359 ± 97 ms, and cMRF5-hb 1,357 ± 76 ms. The mean myocardial T2 measured with the conventional mapping technique was 41.7 ± 6.7 ms, while for cMRF15-hb 29.6 ± 5.8 ms and cMRF5-hb 30.5 ± 5.8 ms. T2 was reduced with vasoconstriction (post-hyperventilation compared to a baseline resting state) (30.15 ± 1.53 ms vs. 27.99 ± 2.07 ms, p = 0.02), while T1 did not change with hyperventilation. During the vasodilatory breath-hold, no significant change of myocardial T1 and T2 was observed.
CONCLUSIONS
cMRF5-hb enables simultaneous mapping of myocardial T1 and T2, and may be used to track dynamic changes of myocardial T1 and T2 during vasoactive combined breathing maneuvers.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy > Partial clinic Insel 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy |
UniBE Contributor: |
Fischer, Kady Anne |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2586-7296 |
Publisher: |
Korean Society of Echocardiography |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 Apr 2023 10:40 |
Last Modified: |
27 Apr 2023 02:05 |
Publisher DOI: |
10.4250/jcvi.2022.0080 |
PubMed ID: |
37096671 |
Uncontrolled Keywords: |
Breathing exercises Magnetic resonance imaging Multiparametric magnetic resonance imaging Myocardium |
BORIS DOI: |
10.48350/181993 |
URI: |
https://boris.unibe.ch/id/eprint/181993 |
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