Anschuetz, Lukas; Hohenberger, Ralph; Kaecker, Christoph; Elicin, Olgun; Giger, Roland; Caversaccio, Marco (2023). Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome. Journal of Otolaryngology - Head and Neck Surgery, 52(1), p. 36. BioMed Central 10.1186/s40463-023-00627-8
|
Text
s40463-023-00627-8.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
BACKGROUND
To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome.
METHODS
Patients (n = 144) with malignant tumors of the nasal cavity and paranasal sinuses were treated at our tertiary referral center between 2008 and 2019. A chart review on patient and tumor characteristics, treatment and long-term outcome was performed.
RESULTS
Most frequent histological types were squamous cell carcinoma (SCC) (n = 74), adenocarcinoma (n = 24) and mucosal melanoma (n = 18). Primary therapy was surgery in 66% of patients (n = 95) of which 65.8% (n = 66) received adjuvant radiotherapy. Twenty patients (13.8%) were initially staged as cN + and in seven cases, pN + status was histopathologically confirmed. Fifty-six of 130 patients (43.1%) had a relapse after curative intended therapy, including nine loco-regional (6.9%) and seven isolated regional recurrences (5.4%). Twelve of these 16 patients with (loco-)regional recurrence had SCC. Adenoid cystic carcinoma (87.5%) and SCC (65.3%) showed the best long-term overall survival.
CONCLUSIONS
Regional involvement and regional recurrence are scarce. Because of rarity and heterogeneity, evidence on therapeutic management is sparse resulting in the lack of clinical guidelines.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
UniBE Contributor: |
Anschütz, Lukas Peter, Hohenberger, Ralph Christian, Käcker, Christoph, Eliçin, Olgun, Giger, Roland, Caversaccio, Marco |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1916-0216 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
02 May 2023 10:34 |
Last Modified: |
07 May 2023 02:26 |
Publisher DOI: |
10.1186/s40463-023-00627-8 |
PubMed ID: |
37118840 |
Uncontrolled Keywords: |
Mucosal melanoma Nasal cancer Rare cancer Regional recurrence Squamous cell carcinoma |
BORIS DOI: |
10.48350/182126 |
URI: |
https://boris.unibe.ch/id/eprint/182126 |
Actions (login required)
 |
Edit item |