Role of Lp(a) in patients with erectile dysfunction undergoing angioplasty for symptomatic pelvic artery disease.

Kalka, Christoph; Lippik, Lisa; Wenzel, Folker; Hoppe, Hanno; Keo, Hak-Hong; Heiss, Christian; Diehm, Nicolas (2023). Role of Lp(a) in patients with erectile dysfunction undergoing angioplasty for symptomatic pelvic artery disease. Vasa : European journal of vascular medicine, 52(4), pp. 230-238. Hogrefe 10.1024/0301-1526/a001072

Full text not available from this repository.

Background: Atherosclerotic disease of erection-related arteries is a major reason for erectile dysfunction (ED). Lp(a) has been implied in the pathophysiology of atherosclerosis in the coronary and lower limb arteries. Here, we investigated if Lp(a) plays a specific role in ED due with symptomatic pelvic artery atherosclerosis. Patients and methods: Out of 276 consecutive patients treated for ED with angioplasties on proximal (69%) and distal (31%, distal to Alcock channel) erection-related arteries, 236 patients (age: 62±10 years) of which Lp(a) values were available were retrospectively analyzed. Results: The baseline International Index of Erectile Function-15 (IIEF-15) score was 29±15 and significantly increased to 43±20 (increase: 14±21) after treatment at average follow up of 286±201 days. In 25%, Lp(a) values were elevated to more than 30 mg/dL. Hypercholesterolemia, coronary, lower extremity peripheral, and polyvascular disease were more common in patients with Lp(a) ≥60 mg/dl. Anatomic arterial lesion distribution (proximal/distal), improvement in IIEF-15 and clinically driven re-intervention rate (overall 7%) did not differ between patients with <30, 30-59, and ≥60 mg/dL Lp(a). Conclusions: While angioplasty is an effective therapy for ED of arterial origin in patients with obstruction of erection-related arteries, Lp(a) does not seem to play a major role for clinical outcomes in these patients.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology 04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology
UniBE Contributor:	Hoppe, Hanno, Diehm, Nicolas Alexander
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0301-1526
Publisher:	Hogrefe
Language:	English
Submitter:	Pubmed Import
Date Deposited:	02 May 2023 12:03
Last Modified:	04 Jul 2023 00:14
Publisher DOI:	10.1024/0301-1526/a001072
PubMed ID:	37122263
Uncontrolled Keywords:	Lipoprotein(a) endovascular treatment erectile dysfunction penile artery
URI:	https://boris.unibe.ch/id/eprint/182184