Lu, Jiaying; Zhang, Zhengwei; Wu, Ping; Liang, Xiaoniu; Zhang, Huiwei; Hong, Jimin; Clement, Christoph; Yen, Tzu-Chen; Ding, Saineng; Wang, Min; Xiao, Zhenxu; Rominger, Axel; Shi, Kuangyu; Guan, Yihui; Zuo, Chuantao; Zhao, Qianhua (2023). The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer's disease. NeuroImage: Clinical, 38, p. 103416. Elsevier 10.1016/j.nicl.2023.103416
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PURPOSE
Left-right asymmetry, an important feature of brain development, has been implicated in neurodegenerative diseases, although it's less discussed in typical Alzheimer's disease (AD). We sought to investigate whether asymmetric tau deposition plays a potential role in AD heterogeneity.
METHODS
Two independent cohorts consisting of patients with mild cognitive impairment due to AD and AD dementia with tau PET imaging were enrolled [the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort with 18F-Flortaucipir, the Shanghai Memory Study (SMS) cohort with 18F-Florzolotau]. Based on the absolute global tau interhemispheric differences, each cohort was divided into two groups (asymmetric versus symmetric tau distribution). The two groups were cross-sectionally compared in terms of demographic, cognitive characteristics, and pathological burden. The cognitive decline trajectories were analyzed longitudinally.
RESULTS
Fourteen (23.3%) and 42 (48.3%) patients in the ADNI and SMS cohorts showed an asymmetric tau distribution, respectively. An asymmetric tau distribution was associated with an earlier age at disease onset (proportion of early-onset AD: ADNI/SMS/combined cohorts, p = 0.093/0.026/0.001) and more severe pathological burden (i.e., global tau burden: ADNI/SMS cohorts, p < 0.001/= 0.007). And patients with an asymmetric tau distribution were characterized by a steeper cognitive decline longitudinally (i.e., the annual decline of Mini-Mental Status Examination score: ADNI/SMS/combined cohorts, p = 0.053 / 0.035 / < 0.001).
CONCLUSIONS
Asymmetry in tau deposition, which may be associated with an earlier age at onset, more severe pathological burden, and a steeper cognitive decline, is potentially an important characteristic of AD heterogeneity.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Lu, Jiaying, Hong, Jimin, Clement, Christoph Ludwig, Rominger, Axel Oliver, Shi, Kuangyu |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2213-1582 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
04 May 2023 10:34 |
Last Modified: |
17 Jun 2023 00:14 |
Publisher DOI: |
10.1016/j.nicl.2023.103416 |
PubMed ID: |
37137254 |
Uncontrolled Keywords: |
Age Alzheimer’s disease Asymmetry Positron emission tomography Prognosis Tau |
BORIS DOI: |
10.48350/182290 |
URI: |
https://boris.unibe.ch/id/eprint/182290 |
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