Richter, Johannes K; Vallesi, Vanessa; Zölch, Niklaus; Chan, Kimberly L; Hunkeler, Nadine; Abramovic, Mihael; Hashagen, Claus; Christiaanse, Ernst; Shetty, Ganesh; Verma, Rajeev K; Berger, Markus F; Frotzler, Angela; Eisenlohr, Heidrun; Eriks Hoogland, Inge; Scheel-Sailer, Anke; Wyss, Patrik O (2023). Metabolic profile of complete spinal cord injury in pons and cerebellum: A 3T 1H MRS study. Scientific reports, 13(1), p. 7245. Springer Nature 10.1038/s41598-023-34326-1
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The aim of this exploratory study was the assessment of the metabolic profiles of persons with complete spinal cord injury (SCI) in three region-of-interests (pons, cerebellar vermis, and cerebellar hemisphere), with magnetic resonance spectroscopy, and their correlations to clinical scores. Group differences and association between metabolic and clinical scores were examined. Fifteen people with chronic SCI (cSCI), five people with subacute SCI (sSCI) and fourteen healthy controls were included. Group comparison between cSCI and HC showed lower total N-acetyl-aspartate (tNAA) in the pons (p = 0.04) and higher glutathione (GSH) in the cerebellar vermis (p = 0.02). Choline levels in the cerebellar hemisphere were different between cSCI and HC (p = 0.02) and sSCI and HC (p = 0.02). A correlation was reported for choline containing compounds (tCho) to clinical scores in the pons (rho = - 0.55, p = 0.01). tNAA to total creatine (tNAA/tCr ratio) correlated to clinical scores in the cerebellar vermis (rho = 0.61, p = 0.004) and GSH correlated to the independence score in the cerebellar hemisphere (rho = 0.56, p = 0.01). The correlation of tNAA, tCr, tCho and GSH to clinical scores might be indicators on how well the CNS copes with the post-traumatic remodeling and might be further examined as outcome markers.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology |
UniBE Contributor: |
Richter, Johannes Konstantin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
09 May 2023 10:22 |
Last Modified: |
21 May 2023 02:25 |
Publisher DOI: |
10.1038/s41598-023-34326-1 |
PubMed ID: |
37142669 |
BORIS DOI: |
10.48350/182346 |
URI: |
https://boris.unibe.ch/id/eprint/182346 |
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