Adaptive Deep Brain Stimulation: From Experimental Evidence Toward Practical Implementation.

Neumann, Wolf-Julian; Gilron, Roee; Little, Simon; Tinkhauser, Gerd (2023). Adaptive Deep Brain Stimulation: From Experimental Evidence Toward Practical Implementation. Movement disorders, 38(6), pp. 937-948. Wiley 10.1002/mds.29415

Movement_Disorders_-_2023_-_Neumann_-_Adaptive_Deep_Brain_Stimulation_From_Experimental_Evidence_Toward_Practical.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (1MB) | Preview

Closed-loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at an unprecedented temporal precision for neurological disorders. This has the potential to lead to a breakthrough in neurotechnology, but the translation to clinical practice remains a significant challenge. Via bidirectional implantable brain-computer-interfaces that have become commercially available, aDBS can now sense and selectively modulate pathophysiological brain circuit activity. Pilot studies investigating different aDBS control strategies showed promising results, but the short experimental study designs have not yet supported individualized analyses of patient-specific factors in biomarker and therapeutic response dynamics. Notwithstanding the clear theoretical advantages of a patient-tailored approach, these new stimulation possibilities open a vast and mostly unexplored parameter space, leading to practical hurdles in the implementation and development of clinical trials. Therefore, a thorough understanding of the neurophysiological and neurotechnological aspects related to aDBS is crucial to develop evidence-based treatment regimens for clinical practice. Therapeutic success of aDBS will depend on the integrated development of strategies for feedback signal identification, artifact mitigation, signal processing, and control policy adjustment, for precise stimulation delivery tailored to individual patients. The present review introduces the reader to the neurophysiological foundation of aDBS for Parkinson's disease (PD) and other network disorders, explains currently available aDBS control policies, and highlights practical pitfalls and difficulties to be addressed in the upcoming years. Finally, it highlights the importance of interdisciplinary clinical neurotechnological research within and across DBS centers, toward an individualized patient-centered approach to invasive brain stimulation. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Tinkhauser, Gerd


600 Technology > 610 Medicine & health








Pubmed Import

Date Deposited:

08 May 2023 15:29

Last Modified:

22 Jul 2023 00:14

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Parkinson's disease adaptive DBS basal ganglia closed loop DBS local field potentials




Actions (login required)

Edit item Edit item
Provide Feedback